Picard: "I'm about to commit a direct violation of our orders. Any of you who wish to object should do so now, it will be noted in my log."
Data: "Captain, I believe I speak for everyone here when I say... To Hell with our orders."

Riker: (To Worf)"You do remember how to fire phasers...?"

Crusher: "I swore I'd never use one of these. Computer, activate the EMH program."
EMH: "Please state the nature of the medical emergency."
Crusher: "20 Borg are about to break through that door. We need time to get out of here. Create a diversion."
EMH: "This isn't part of my program. I'm a doctor, not a doorstop."
Crusher: "Well, do a dance, tell a story, I don't care! Just give us a few seconds."
EMH: (To Borg)"According to Starfleet Medical research, Borg implants can cause sever skin irritations. Perhaps you'd like an analgesic cream...?"

Troi: "Will, I think we have to tell him the truth."
Riker: "If we tell him the truth, the timeline..."
Troi: "Timeline? This is no time to argue about time! We don't have the time!" (Pauses) "What was I saying?"

Troi: "If you're looking for my professional opinion as ship's counselor, he's nuts."
Riker: "I'll be sure to note that in my log."

Cochrane: "...And you people, you're all...astronauts...on some kind of star trek?"

Picard: "Maximum setting. If you'd fired this, you'd have vaporized me."
Lily: "It's my first ray gun."

Cochrane: "I don't want to be a statue!"

Riker: "You told him about the statue?"

Worf: (To Borg) "Assimilate this!"

Picard: "We have not lost the Enterprise, Mr. Worf. We are not going to lose the Enterprise. Not to the Borg, not while I'm in command."

Picard: "I will not sacrifice the Enterprise. We make too many comprimises already, too many retreats. They invade our space, and we fall back. They assimilate entire worlds, and we fall back. Not again. The line must be drawn here! This far, and no farther. And I will make them pay for what they have done!"
Lily: "You broke your little ships."

Crusher: "So much for the Enterprise-E"
Picard: "We barely knew her."
Crusher: "Think they'll build another one?"
Picard: "Plenty of letters in the alphabet."