When Christ comes, the Antichrist is destroyed:
2 Thes 2:8
Then shall that Wicked be revealed, whom the
Lord shall... destroy with the brightness of
his coming...
The Antichrist is destroyed at the 2nd
coming:
Rev 19:20
And the beast was taken, and... cast alive
into a lake of fire burning with brimstone.
The Antichrist isn't destroyed at the 6th seal,
for he gathers his armies at the 6th vial.
At the 6th vial Jesus says "Behold, I come
as a thief," so He hasn’t come by then.
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The Bible doesn't separate the 7 vials of wrath
from the tribulation.
The 6th seal isn't after the tribulation because
after the 6th seal comes the 7th seal and the 7
trumpets and the 7 vials, which are all part of
the tribulation.
The coming of Christ and the rapture must bring
all of the tribulation, including the 7 vials of
wrath, to an end, so that some flesh might survive
on the earth:
Matt 24:21-22
For then shall be great tribulation, such as was
not since the beginning of the world to this
time, no, nor ever shall be. And except those
days should be shortened, there should no flesh
be saved: but for the elect's sake those days
shall be shortened.
This is why we don’t see His coming until Rev 19,
after the 7th vial has already been poured out in Rev 16.
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1 Thes 5:9
God hath not appointed us to wrath, but to
obtain salvation by our Lord Jesus Christ...
Here wrath doesn't mean the 7 vials,
and salvation doesn't mean the rapture.
The wrath our salvation delivers us from
is God's eternal wrath:
John 3:36
He that believeth on the Son hath everlasting
life: and he that believeth not the Son shall
not see life; but the wrath of God abideth
on him.
There is a wide range to his wrath:
Mark 3:5
He... looked round about on them with anger (orge).
1 Thes 5:9
God hath not appointed us to wrath (orge).
We can be appointed to the 7 vials without
losing our salvation.
We can be appointed to the 7 vials without
being appointed to His eternal wrath in hell.
And if we read through Rev. 16, we see that none of the
7 vials which will come directly from the hand of God will
be directed at Christians. The 1st vial will be directed
only at those who take the mark, the 2nd will be
directed at the sea, the 3rd at the rivers, the 4th at
the sun, the 5th at the kingdom of the beast, the 6th at
the river Euphrates, and the 7th will bring a great
earthquake and huge hailstones.
Even if some Christians can't find any fresh water in
the 3rd vial or are unsheltered from the sun in the 4th,
they won't experience anything much worse than Christians
who have suffered and died in droughts and burning heats
throughout history. Even if they're struck by the stones
that will fall on the earth in the 7th vial, it won't
mean that God directed the stones at them, just as
hurricanes and earthquakes kill faithful Christians today.
We need not fear suffering or dying in the tribulation,
for we will receive great reward for our sufferings
(1 Pet 4:19, Rev 2:10, Heb 11:35), and even death can't
keep us from our salvation.
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The great multitude can’t be the entire Church
because later we find other saints dying under
Antichrist's rule (Rev 13:10; 14:12-13), which
comes after the trumpets (Rev 8-11). Also, no
place does it say the great multitude got there by
a rapture. They are Christians who die in the nuclear
war and its aftereffects of the 2nd through 4th seals
(Rev 6:4-8), or through the martyrdom of the 5th
seal (Rev 6:9-11).
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There Christians on the earth even after the
144,000 are in heaven:
Rev 14:3, 12-13
And they sung as it were a new song before the
throne, and before the four beasts, and the elders:
and no man could learn that song but the hundred and
forty and four thousand, which were redeemed from
the earth... Here is the patience of the saints:
here are they that keep the commandments of God,
and the faith of Jesus. And I heard a voice from
heaven saying unto me, Write, Blessed are the dead
which die in the Lord from henceforth: Yea, saith
the Spirit, that they may rest from their labours;
and their works do follow them.
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This phrase by terrified unbelievers can't be
interpreted technically because the wrath of God doesn't
begin immediately after the 6th seal. After the 6th seal
comes the 7th seal and the 7 trumpets, and noone in
heaven calls them the wrath of God.
The wrath of God "is come" at the 7th trumpet (Rev 11:18),
and is in the 7 vials of the wrath of God (Rev 16:1)
which are the final stage of the tribulation.