Pineal gland activation in rats with colon tumors induced by 1,2-dimethylhydrazine

Sibarov D.A., Kovalenko R.I., Anisimov V.N., Nozdrachev A.D.
Pineal gland activation in rats with colon tumors induced by 1,2-dimethylhydrazine
Federation of European Neuroscience Societies (Millenium meeting) p.225, N107.4, (24-28 june ) 2000, Brighton, U.K.

The pineal glands of intact rats and rats with 1,2-dimethylhydrazine induced tumors of large intestine, were electrophysiologically studied in the day-time. Extracellulary recorded cellular spikes frequency were analysed. The existence of different types of pinealocytes in the pineal gland was confirmed. Tumor-bearing rats, in comparison to intact, demonstrated higher spikes frequency due to cells switching from regular to pattern (4-6 times gain) activity and appearance of «fast» cells (>5Hz frequency). The literature about pinealocytes points on the correlation between electrical and secretory processes in pinealocytes, thus we suppose the groups of interacting cells, detected in tumor-bearing rats, to reflect cascade cells activation while pineal gland secretion increase. The electrical stimulation of olfactory epithelium significantly decreased the total spikes frequency in intact and tumor-bearing rats. Thus, in the day-time pinealocytes are secreting substances (not melatonin) in dependence with hormonal background and sensory input, olfactory in particular.

Back to:	Publications	Main Page	http://sibarov.da.ru

Sibarov D.A., Kovalenko R.I., Anisimov V.N., Nozdrachev A.D. Pineal gland activation in rats with colon tumors induced by 1,2-dimethylhydrazine Federation of European Neuroscience Societies (Millenium meeting) p.225, N107.4, (24-28 june ) 2000, Brighton, U.K. The pineal glands of intact rats and rats with 1,2-dimethylhydrazine induced tumors of large intestine, were electrophysiologically studied in the day-time. Extracellulary recorded cellular spikes frequency were analysed. The existence of different types of pinealocytes in the pineal gland was confirmed. Tumor-bearing rats, in comparison to intact, demonstrated higher spikes frequency due to cells switching from regular to pattern (4-6 times gain) activity and appearance of «fast» cells (>5Hz frequency). The literature about pinealocytes points on the correlation between electrical and secretory processes in pinealocytes, thus we suppose the groups of interacting cells, detected in tumor-bearing rats, to reflect cascade cells activation while pineal gland secretion increase. The electrical stimulation of olfactory epithelium significantly decreased the total spikes frequency in intact and tumor-bearing rats. Thus, in the day-time pinealocytes are secreting substances (not melatonin) in dependence with hormonal background and sensory input, olfactory in particular.