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Home
> Psicofármacos
> Anorexígenos
> Mazindol
Commercial Names:
They sharpen, Dimagrir, Fastin, Ilezol, Liofindol, Obendol, Samonter, Sanorex, Solucaps, Tenorac.
Therapeutic Action:
Treatment of the exogenous obesity in the short term (of 6 to 8 weeks),
in adults and greater children of 12 years, like helping of the poor
diet in calories.
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 Farmacocinética
Dosage
Effects to dversos
Warnings
Precautions
Interactions
Contraindications
Sobredosificación
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Indications:
The Mazindol
is indicated in the treatment of the obesity as complement of the
hypocaloric diet, as much to diminish of weight as in the maintenance
of the diminution of weight.
Farmacodinamia:
The M azindol, imidazoisoindol tricyclic pertaining to a new class of
chemistry of anorexígenos. Unlike the carried out investigations with
drugs like the amphetamine and its derivatives, the studies with
mazindol demonstrate that there are certain differences, with regards
to the place and mechanisms of action of mazindol and suppresors of the
appetite of the anfetamínico type. Clinical studies have demonstrated
that, even though mazindol has certain estimuladoras properties of the
SNC, their quality is significantly different from the
feniletilamínicos derivatives. In these investigations there are
accumulated tests that they indicate that mazindol does not induce
dependency or phenomenon by ricochet.
Farmacocinética:
The absorption of Mazindol takes place with an average life of 1 hour.
2 a unique oral dose of 1 or mg can be detected in the blood after 10
minutes.
The maximum plasmáticas concentrations are reached after 3,6 hours on
the average. The union to plasmáticas proteins is of 77%. The average
life of elimination in plasma is of 10 hours approximately. The urinary
excreción of the inalterable substance and the metabolitos ascends to
40-50% of which around 4% they represent the inalterable substance.
Dosage and Way of Administration :
It is recommended to once begin the treatment with a daily dose of 1mg
to the day one hour before the breakfast, with increases of 1mg twice
to the day, one hour before the meals, or of 2mg, once to the day, one
hour before the lunch. The treatment does not have to be superior to 8
weeks. If the treatment is due to repeat it will have to observe an
interval without medication that is not inferior to the period of
preceding treatment.
Adverse Effects :
The registered adverse secondary reactions more are dryness of mouth,
nervousness, constipación (possibly due to the changes in the
nourishing habits) and upheavals of the dream. Less frequent indirect
effect are nausea, vomit, migraine, I navigate, tachycardia, reversible
of the micción of the sexual function and the sudación. In isolated
cases cutaneous eruptions of the hypertension have been registered,
sincerely, diarrea pain and bad flavor of mouth. The treatment will be
due to interrupt if they appear allergic symptoms.
Warnings:
The use of anorexígenos in minors of 12 years is not recommended. If
the suspicion of physical or psychic dependency exists, to consult with
the doctor. They can reduce the sugar levels in blood in the diabetics.
They are only recommended for the use in the short term; when it is
suspended, after a prolonged administration, the metering is due to
reduce in gradual form.
Precautions:
Use during the pregnancy and lactancia:
In diabetic patients, the suppresor administration of the appetite and
the concomitante dietetic regime can modify the sanguineous glucose
concentrations. Mazindol can affect the oral answer to the insulin and
hipoglucemiantes, reason why the metabolic state of the patient will
have to throughout stay in observation the treatment. The dose of
insulin and oral hipoglucemiantes can need a readjustment. Precaution
in the presence of psychosis is required. Mazindol does not recommend
in smaller children of 12 years nor in patients of age outpost. The
patients whom they have to drive vehicles or to handle machines will
have to control first their reaction to the drug.
Alterations of the laboratory tests:
They have not been reported.
Carcinogénesis, Mutagénesis, Teratogénesis and alterations of the Fertility:
They have not been reported.
Medicamentosas interactions:
Their possible interactions with inhibiting medicines of the MAO must
be considered, reason why 2 weeks must be suspended before the
treatment with Mazindol.
Contraindications:
Well-known Hipersensibilidad to the Mazindol, glaucoma of close angle,
renal, hepática insufficiency and/or cardiac serious; arrhythmias
cardiac, serious hypertension, hiperexcitabilidad, states of agitation
and antecedents of drug abuse.
Sobredosificación :
Symptoms: Nausea, vomit, migraine, tachycardia, arrhythmia cardiac, disnea, alterations of the micción, excitation, convulsions, comma.
Treatment: Elimination of the drug by gastric washing,
followed of the activated charcoal administration. If it is necessary,
the symptomatic treatment of support and monitoring of the
cardiovascular and respiratory system. In case of excitation and
convulsions; barbiturates of fast action or benzodiazepinas.
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