WHAT CAUSES FMS?

The cause of FMS remains elusive, but there are many triggering events thought to precipitate its onset.  A few examples would be an infection (viral or bacterial), an automobile accident or the development of another disorder, such as rheumatoid arthritis, lupus or hypothyroidism.  These triggering events probably don't cause FMS, but rather, they may awaken an underlying physiological abnormality that's already present.

What could this abnormality be?  Theories pertaining to alterations in pain-related chemical transmitters (particularly substance P, seratonin and nonrepinephrine), immune system function, sleep physiology and hormonal control are under investigation.  In addition, modern brain imaging techniques are being used to explore various aspects of brain function.  The body's response to exercise, stress and simple alterations in position (vertical versus horizontal) are also being evaluated.
In addition, substance P is increased threefold in the spinal fluid of people with FMS, but it is normal in the blood.  Substance P is a major pain transmitter and plays a role in sleep, digestion, and other body functions.  Ironically, many of the drugs prescribed for FMS/CMS may have a favorable impact on there transmitters as well.

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