Estradiol Cypionate
Brand Name Manufacturers Depo-Estradiol by Pharmacia/Upjohn
Generic Manufacturers Depogen by Hyrex
Dep-gynogen by Forest
Estro-cyp by Keene
Goldline
Moore
Rugby
Steris
Pharmacology Ester with estradiol same effect as endogenous estrogen
Delivery Sustained release intramuscular injection,
Availability Approved by U.S. FDA
Indications Estrogen replacement therapy in females
Contraindications Active blood clotting disorders. Estrogen-dependent tumors. History of blood clotting disorders associated with estrogen use. History of sensitivity to estradiol or any part of the preparation. Known or suspected breast cancer except in appropriately selected patients.
Adverse reactions CNS
Convulsions. Dizziness. Headache. Migraine. Mental depression. Spasms of limb and facial muscles.
Eyes
Intolerance to contact lenses. Steepening of corneal curvature.
Gastrointestinal
Abdominal cramps. Bloating. Cholestatic jaundice. Nausea. Vomiting.
Skin
Blotchy skin pigmentation. Localized skin irritation. Loss of scalp hair. Increase of body hair. Red skin patches from capillary congestion.
Other
Blood clotting disorders. Elevated blood pressure. Fluid retention. Glucose intolerance. Increased serum calcium level. Increased sensitivity to light. Liver tumors.