Peter: Once in your life let go.
Amanda: And once in your life Peter, shut up and drive.

Peter: What is this?
Michael: Looks like a lawsuit.

(Lexi coming back from the trip to New York, after meeting Ryan's three ex fiance's. She's talking to Megan.)
Megan: You were drinking on the plane, weren't you?

(Jane wants a divorce because Michael for the millionth time cheated on her.)
Michael: I was cheating on the hospital, not you.

Jane to Michael: Have a rotten life.

Ryan's ex-fiance: Being engaged to Ryan McBride is the kiss of death.

Michael, Megan, and Ryan: SHUT UP LEXI!!

Kyle: Ryan has a daughter.
Megan: Since when?

Michael: How come I don't get a show?
Lexi: Cause you're not a millionaire.

Michael: You know what? I don't even like your shower. It's got mildew.

Peter: Can we stop hurting each other?
Eve: Yeah, when you're dead and in hell.

Doctor Bisconti: You know Peter without your love life, I'd be out of business.

Dr. Irene: ...Live like a rat, die like a rat.

Peter: Just think about what our romance has survived, huh? Husbands, wives - psychopaths.