ISOREL Therapy - Rules for the Malignant Growth Therapy


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ISOREL Preparations

ISOREL A (Viscum album from fir tree)
ISOREL M (Viscum album from apple tree)
ISOREL P (Viscum album from pine tree)

Sizes of Packet

Normal size with 8 ampoules of 1 ml of strengths 1,6,12,24,36,60
Large Size with 50 ampoules of 1 ml of strength 60

Packet Series I with 8 ampoules of 1 ml each as below:
1 ampoule of strength 1 , 3 ampoules of strength 6 , 4 ampoules of strength 12

Packet Series II with 8 ampoules of 1 ml each as below:
4 ampoule of strength 24 , 4 ampoules of strength 36

Packet Series III with 8 ampoules of 1 ml each as below:
2 ampoule of strength 24 , 2 ampoules of strength 36 , 4 ampoules of strength 60

Packet Series IV with 8 ampoules of 1 ml each as below:
2 ampoule of strength 1 , 2 ampoules of strength 6 , 2 ampoules of strength 12 , 1 ampoule of strength 24 , 1 ampoule of strength 36

Composition

A 1 ml injectable soultion contains the aqueous extract from 60 mg of whole shoots of mistletoe,the subspecies fir,apple and pine in each case. Standardised in-process and final controls guarantee constant quality of each supply.

Means of Application

Hypodermic injection (i.m / s.c)

Durability

2 years. Expiration date mentioned on packet and ampoule.

Areas of Application

For the medicative treatment of malignant tumours,postoperative and recidivation and prophylaxis of metastases,malignant illness of the haemopoietic system,defined precancerous stages.

Reasons for Treatment

On the basis of many years of medical experience about its effectiveness.

ISOREL A

Principally in men:
Tumors of the mouth and the digestive tract ; tumors of the larynx, the respiratory system , the lungs ; tumors of the sense organs ; intracranial tumors ; tumors of the male urogenital system , prostate gland. Independent of sex in case of acute leukemia in children as an additional therapy to chemotherapy ; acute leukemia in addition to chemotherapy ; acute myeloid leukemia. Plasmacytoma.

ISOREL M

Principally in women:
Carcinoma of the mamma ; tumors of the female digestive and urogenital systems. Carcinoma of the lungs. Carcinoma of the liver and gall bladder and precancerous stages in women.

ISOREL P

Independent of sex:
Tumors of the skin, melanoma and melanosarcoma ; tumors of the lips, tongue and the throat. Seminoma and testicular teratocarcinoma ; lymphogranulomatosis ; non-Hodgkin lymphoma ; for stimulation of the bone marrow function.

Please note that all the three above mentioned types of ISOREL are equally effective against any type of cancer and the above broad classification is based on many decades of experience with Mistletoe plants. For cancer types not listed above , any ISOREL type can be used.

Therapeutic effects of ISOREL

Through careful choice of the biological source material (Viscum album / Mistletoe) and based on a particularly careful procedure with the preparation, avoiding every denaturing manipulation, whereby the high sensitivity of the active tumour protein is corresponded to a high biological activity of the ISOREL preparation is guaranteed which is Selective cancerostatic effect and stimulation of immune system
Both these bilogical activities are available together in ISOREL which is not available in any oncological therapy.
The improvement in the subjective state of health and the positive effect on the general condition of the patient , the absence of appreciable side-effects apart from minor local reactions are the essential characterstics of the ISOREL preparation.


Rules for the Therapy of Inoperable Tumors

Inoperability arising from unwillingness of the patient to undergo surgery or from reasons against operating in particular case. The therapeutic dose is calculated weekly. Begin fundamentally with a low dose and increase successively.

Stage I Tumor (T1,N0,M0) upto 2cm in diameter without infestation of the lympathic nodules.
Introductory phase: In the first 2 weeks , 3 x 1 ampoules of strength 60 , weekly. If it is necessary , begin with a small initial dose and increase gradually to optimum amount. This can be achieved with packet series I , II and III. The packet series III leads over to the tumor therapy of strength 60. Subsequent weekly dose of 6 ampoules of strength 60 is recommended as follows :

MON WED FRI SAT SUN MON WED FRI SAT SUN
1 2 3 --- --- 3 2 1 --- --- ampoules


Stage II Tumor (T2,N1,M0) 2 - 5 cm in size. Regional infestation of the lympathic nodules.
Introductory phase: In the first 2 weeks , 3 x 1 ampoules of strength 60 , weekly. If it is necessary , begin with a small initial dose and increase gradually to optimum amount. This can be achieved with packet series I , II and III. The packet series III leads over to the tumor therapy of strength 60. Subsequent weekly dose of 9 ampoules of strength 60 is recommended as follows :

MON WED FRI SAT SUN MON WED FRI SAT SUN
2 3 4 --- --- 4 3 2 --- --- ampoules


Stage III / IV Tumor (T3-T4,N2,M1) 5 - 10 cm or more in size. Extends beyond organ boundaries ; infestation of the entire lymph gland sectors ; metastases ; inoperable recidive tumors.
Introductory phase: In the first 2 weeks , 3 x 1 ampoules of strength 60 , weekly. If it is necessary , begin with a small initial dose and increase gradually to optimum amount. This can be achieved with packet series I , II and III. The packet series III leads over to the tumor therapy of strength 60. Subsequent weekly dose of 12 ampoules of strength 60 is recommended as follows :

MON WED FRI SAT SUN MON WED FRI SAT SUN
3 4 5 --- --- 5 4 3 --- --- ampoules


Depending on the case , the doctor can decide to increase the weekly dose up to 20 ampoules of strength 60. The maximum dose of 7 ampoules per day can not be exceeded. As soon as the laboratory status shows standard values and tumor parameters show favourable tendency , the weekly dose can be reduced to suit the case.
Laboratory progress controls such as BSR , Hb , Ery , Leuko , Mo , Eo , Lympho , LDH , Bilrubin , Y-Globulin , Tumormarker etc. should ensue regularly.

Place of application

At a favourable location near the tumor. The place of application should be varied , especially in the case of local reactions (redness) at the puncture site. For the guarantee of long term therapy , the patient can inject ISOREL himself subcutaneously , following the instruction by the doctor. In the case of incompatibility of one of the types of ISOREL , change to another.


Rules for the Postoperative and Postradial Recidivation and Metastases Prophylaxis

Begin the prophylactic ISOREL therapy immediately after the surgery and radiation wherever possible.

Stage I and II (Diagnosis at the time of surgery/radiation)
Introductory phase: In the first 2 weeks , 3 x 1 ampoules of strength 60 , weekly. If it is necessary , begin with a small initial dose and increase gradually to optimum amount. This can be achieved with packet series I , II and III. The packet series III leads over to the tumor therapy of strength 60. Subsequent weekly dose of 6 ampoules of strength 60 is recommended as follows :

MON WED FRI SAT SUN MON WED FRI SAT SUN
1 2 3 --- --- 3 2 1 --- --- ampoules


Stage III and IV (Diagnosis at the time of surgery/radiation)
Introductory phase: In the first 2 weeks , 3 x 1 ampoules of strength 60 , weekly. If it is necessary , begin with a small initial dose and increase gradually to optimum amount. This can be achieved with packet series I , II and III. The packet series III leads over to the tumor therapy of strength 60. Subsequent weekly dose of 6 ampoules of strength 60 is recommended as follows :

MON WED FRI SAT SUN MON WED FRI SAT SUN
2 3 4 --- --- 4 3 2 --- --- ampoules


As nearly all recidivation appears in the first 3 years following the operation , it is recommended that the specified therapy be continued for 3 years. In the case of good results , the weekly dose can be reduced to 3 x 1 ampoule of strength 60 per week from the 4th year.

In the majority of cases , the prophylactic recidivation therapy can be considered after 7th year. The doctor can decide to assign a prophylactic conservation dose of 1 ampoule of strength 60 per week , intervened by one week break from medication at the end of every month , in cases of strong tendency towards recidivation. (Carcinoma of mamma , malignant melanoma etc. )

Place of application

If possible , inject in the area of surgery (near the scar). In the case of operated intestinal carcinoma and carcinoma of prostate gland , administer in the lower abdomen alternately left and right side. Fundamentally , vary the puncture sites : right , left upper arm , thigh etc. Don't inject in areas showing reaction to radiation.

Precancerous stages

ISOREL treatment of precancerous stages can prevent their degeneration and can also achieve their retardation provided they are not accessible for surgical sanitation such as :

Combined Therapy

Cystostatic chemotherapy and radiation are made more tolerable by a parallel ISOREL treatment.

Desensitisation

In very rare cases of allergic hypersensitivity (such as nettle-like appearances on the skin) the patient should be desensitised with strength 1. After the reaction has disappeared , treatment is continued with the packet series I , II and III 1 ampoule 3 times a week. The packet series III leads to tumour therapy of strength 60.

When not to use ISOREL

Reasons why ISOREL treatment should not be used does not exist. However, it is recommended that the medication be stopped during menstrual period and pregnancy.

Side Effects

Localised reddness at the puncture site can appear. Small increase in temperature of 1 to 1.5 degree Centigrade can be observed which disappear after 1 to 2 days. It is recommended to wait for the normalisation of the temperature before a new injection is administered. In the case of hyperthyroidism , start with low doses and increase gradually. In the case of phlebitis , do not inject in the inflammed areas.

Duration of Use

As long as medical is required. There are no known harmful effects , by long term treatment.

Interaction with other drugs

Nothing observed

Directions for Nutrition

All types of vegetables , above all lactic vegetables (sauerkraut) and lactic vegetable juice (sauerkraut juice). Sour milk, butter milk, cottage cheese , yoghurt , whole meal bread.
Avoid white flour. No sugar (perhaps 1 teaspoon of honey per day) , reduce meat consumption. No tinned meat.

ISOREL is a Product of

NOVIPHARM
A-9210 Portschach
Klagenfurter Str 164
Austria
Tel : 04272-2751-0
Fax : 04272-3119
Contact Person : Udo Sussman , Head of Research

Note: While contacting Novipharm , mention about this web page .

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