Selected Schedules of Therapy for Malignant Tumours

MINI ABSTRACT
   Summary of the chemotherapy of malignant tumours.
Published in: ASTA Medica Oncologica, 8th Edition 1995

Non-Small Cell Lung Cancer

Mesothelioma

Thymoma

NON-SMALL CELL LUNG CANCER

• COMBINATIONS CONTAINING IFOSFAMIDE

Ifosfamide-Cisplatin(IC)

Ifosfamide 1,500-(2,000) mg/m2 i.v. (1h) days 1-5
Cisplatin 75 mg/m2 i.v. (30 min) days 1-5
To be repeated every 4 weeks

LITERATURE:
Drings et al., Dtsch. med. Wschr. 109(1984): 1059-1064

Ifosfamide 2,000 mg/m2 i.v. (30min) days 1-3
Cisplatin 33 mg/m2 i.v. (30 min-1h) days 1-3

LITERATURE:
Graziano et al., Cancer 72 (1993) 62-68

Ifosfamide-Etoposide(IVP)

Ifosfamide 1,500-(2,000) mg/m2 i.v. (short infusion) days 1-5
Etoposide 120 mg/m2 i.v. (short infusion) days 1-3
To be repeated every 4 weeks

LITERATURE:
Manke et al., Cancer Treat. Rev. 10 Suppl. A (1983): 125
Drings et al., Tumordiagn. u. Ther. 11 (1990): 79-84

MESOTHELIOMA

• SINGLE AGENT CHEMOTHERAPY

Epirubicin 110 mg/m2 day 1
To be repeated every 3 weeks
LITERATURE:
Matison et al., J. Clin. Oncol.10 (1992): 824-828

The role of chemotherapy in the management of mesothelioma is currently unclear and no standard regimes are available; see for review (Ruffie, Curr Opin Oncol 10(1992):334-341)

.THYMOMA

• SINGLE AGENT CHEMOTHERAPY

Cisplatin, ifosfamide and corticosteroids are considered to be the most active agents
LITERATURE:
Tomiak and Evans, Crit. Rev. Oncol./Hematol. 15 (1993): 113-124
• ADOC
  Doxorubicin 40 mg/m2 i.v. day 1

  Cisplatin 50 mg/m2 i.v. day 1

  Vincristine 0.6 mg/m2 i.v. day 3

  Cyclophosphamide 700 mg/m2 i.v. day 4
  To be repeated every 3 weeks

  LITERATURE:
  Fornasiero et al., Cancer 68 (1991): 30-33
  Berruti et al., Ann Oncol 4 (1993): 429-431

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