National Library of Medicine: IGM Selected Full Records Screen Full Citations: 1 to 5 of 5 from 1994-97 TITLE: Contact pemphigus. AUTHOR: Vozza A; Ruocco V; Brenner S; Wolf R AUTHOR AFFILIATION: Department of Dermatology, 2nd University of Naples, Italy. SOURCE: Int J Dermatol 1996 Mar;35(3):199-201 NLM CIT. ID: 96235479 MAIN MESH SUBJECTS: *Agriculture Dermatitis, Occupational/DRUG THERAPY/*ETIOLOGY/PATHOLOGY Pemphigus/DRUG THERAPY/*ETIOLOGY/PATHOLOGY ADDITIONAL MESH SUBJECTS: Adult Case Report Dermatitis, Contact/DRUG THERAPY/ETIOLOGY/PATHOLOGY Fluorescent Antibody Technique, Direct Hand Dermatoses/DRUG THERAPY/ETIOLOGY/PATHOLOGY Human Male Patch Tests PUBLICATION TYPES: JOURNAL ARTICLE LANGUAGE: Eng TITLE: Pemphigus and dietary factors. In vitro acantholysis by allyl compounds of the genus Allium. AUTHOR: Brenner S; Ruocco V; Wolf R; de Angelis E; Lombardi ML AUTHOR AFFILIATION: Department of Dermatology, Tel-Aviv Sourasky Medical Center, Israel. SOURCE: Dermatology 1995;190(3):197-202 NLM CIT. ID: 95322662 ABSTRACT: BACKGROUND: Today it is generally accepted that every drug that possesses an active thiol group in its molecule is capable of inducing pemphigus in vivo and provoking acantholysis in vitro. We therefore suggested that plants, in particular those belonging to the Allium group, that contain several active compounds with stable disulfide and thiol groups in their molecule may cause the same. OBJECTIVE: To verify this hypothesis by investigating the in vitro acantholytic effect of three compounds of garlic. METHODS: Skin samples from donors were cultured in the presence of three compounds of garlic (i.e. allylmercaptan, allylmethylsulfide and allylsulfide) for 3 days. The skin samples were then processed for microscopic control for acantholysis. RESULTS: Results indicate that, indeed, the three garlic compounds tested are capable of inducing acantholysis in vitro. Focal and diffuse acantholysis was observed in the specimens from 4 out of 7 donors cultured in the presence of 6 and 9 mM of each of the allyl compounds for 3 days. Interestingly, tissues from a DR4+ donor proved to be more acantholysis prone than others, showing large blistering due to diffuse acantholysis, thus indicating that individual susceptibility plays a crucial role also in vitro. CONCLUSION: Garlic compounds with stable disulfide and thiol groups in their molecule are capable of inducing acantholysis in vitro. These findings lend further support to the theory that 'harmless' nutritional factors are capable of inducing acantholysis in vitro and possibly also in vivo. In view of these findings, it is suggested that nutritional factors should be added to the ever-growing list of exogenous factors capable of inducing pemphigus. MAIN MESH SUBJECTS: Acantholysis/*CHEMICALLY INDUCED/PATHOLOGY Allyl Compounds/*ADVERSE EFFECTS Diet/*ADVERSE EFFECTS *Garlic Pemphigus/*ETIOLOGY Skin/*DRUG EFFECTS/PATHOLOGY ADDITIONAL MESH SUBJECTS: Adult Blister/CHEMICALLY INDUCED/PATHOLOGY Culture Media Disulfides/ADVERSE EFFECTS Female Human HLA-DR4 Antigen/ANALYSIS Middle Age Plant Oils/ADVERSE EFFECTS Sulfhydryl Compounds/ADVERSE EFFECTS Sulfides/ADVERSE EFFECTS Tissue Culture PUBLICATION TYPES: JOURNAL ARTICLE LANGUAGE: Eng REGISTRY NUMBERS: 0 (Allyl Compounds) 0 (Culture Media) 0 (Disulfides) 0 (HLA-DR4 Antigen) 0 (Plant Oils) 0 (Sulfhydryl Compounds) 0 (Sulfides) 2179-58-0 (allyl methyl disulfide) 592-88-1 (allyl sulfide) TITLE: Contact pemphigus: a subgroup of induced pemphigus. AUTHOR: Brenner S; Wolf R; Ruocco V AUTHOR AFFILIATION: Department of Dermatology, Tel Aviv Sourasky Medical Center, Ichilov Hospital, Israel. SOURCE: Int J Dermatol 1994 Dec;33(12):843-5 NLM CIT. ID: 95189343 MAIN MESH SUBJECTS: Dermatitis, Contact/*COMPLICATIONS Pemphigus/*ETIOLOGY ADDITIONAL MESH SUBJECTS: Human PUBLICATION TYPES: JOURNAL ARTICLE REVIEW REVIEW OF REPORTED CASES LANGUAGE: Eng TITLE: Possible nutritional factors in induced pemphigus. AUTHOR: Brenner S; Wolf R AUTHOR AFFILIATION: Department of Dermatology, Ichilov Hospital, Tel Aviv, Israel. SOURCE: Dermatology 1994;189(4):337-9 NLM CIT. ID: 95178771 ABSTRACT: Today it is generally accepted that every drug that possesses an active thiol group in its molecule is capable of inducing pemphigus. Some plants, in particular those belonging to the Allium group, contain several active compounds with stable disulfide and thiol groups in their molecule. The Allium group contains many important vegetables like onion, leek and garlic. Examples of molecules with an active thiol group are: CH2 = CH-CH2-S-S-CH2-CH = CH2 (diallyl disulfide) or CH2 = CH-CH2-S(O)S-CH2-CH = CH2 (allicin). It is suggested that some foods, in particular vegetables of the Allium group that contain active thiol groups in their molecule, could contribute to the induction of pemphigus. In general, nutritional factors should be added to the list of exogenous factors that are capable of inducing pemphigus. MAIN MESH SUBJECTS: *Allium/CHEMISTRY Pemphigus/*ETIOLOGY Sulfhydryl Compounds/*ADVERSE EFFECTS/ANALYSIS Vegetables/*ADVERSE EFFECTS/CHEMISTRY ADDITIONAL MESH SUBJECTS: Disulfides/ADVERSE EFFECTS/ANALYSIS Human Nutrition Sulfinic Acids/ADVERSE EFFECTS/ANALYSIS PUBLICATION TYPES: JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL LANGUAGE: Eng REGISTRY NUMBERS: 0 (Disulfides) 0 (Sulfhydryl Compounds) 0 (Sulfinic Acids) 2179-57-9 (diallyl disulfide) 539-86-6 (allicin) TITLE: An active amide group in the molecule of drugs that induce pemphigus: a casual or causal relationship? AUTHOR: Wolf R; Brenner S AUTHOR AFFILIATION: Department of Dermatology, Tel-Aviv Sourasky Medical Center, Ichilov Hospital, Israel. SOURCE: Dermatology 1994;189(1):1-4 NLM CIT. ID: 94272109 ABSTRACT: Traditionally, drugs that are capable of inducing pemphigus are divided into two main groups according to their chemical structure, in particular, the existence of a sulfhydryl group in their molecule. Thus, two groups are formed: (1) drugs containing a sulfhydryl radical (thiol drugs or SH drugs) and (2) nonthiol or other drugs. Much emphasis has been put on the role of the sulfhydryl group in the pathogenesis of drug-induced pemphigus. The effects of this group have been extensively studied, and a logical paradigm on the mode of its action has been created. However, no attempt has been made to search for other biochemical radicals which might have an influence on the activation/triggering of this disease. The aim of the present report is to draw attention to a chemical group common to the molecule of several drugs that have been associated with the induction of pemphigus. Careful analysis of the chemical structure of nonthiol drugs known to induce pemphigus revealed that several of them share an active amide group in their molecule. We believe that this group might be responsible for the induction of the disease; thus, a third group of drugs capable of triggering pemphigus can be formed, namely drugs containing an active amide group. Several drugs of this group are discussed. MAIN MESH SUBJECTS: Amides/*ADVERSE EFFECTS/ANALYSIS/CHEMISTRY Pemphigus/*CHEMICALLY INDUCED ADDITIONAL MESH SUBJECTS: Cephalosporins/ADVERSE EFFECTS Enalapril/ADVERSE EFFECTS Human Penicillins/ADVERSE EFFECTS Sulfhydryl Compounds/ANALYSIS PUBLICATION TYPES: JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL LANGUAGE: Eng REGISTRY NUMBERS: 0 (Amides) 0 (Cephalosporins) 0 (Penicillins) 0 (Sulfhydryl Compounds) 75847-73-3 (Enalapril) Cumulative cost of this session is $2.66