inclusion
- Model
of the development of the lobed chlamydial inclusion.The model begins
with the EB (filled circle) inside an
early inclusion within the infected cell A). The EB differentiates to an
RB (open oval) which then grows and
multiplies within the growing inclusion B) to D). The inclusion membrane
grows with the growing bacterial membrane
and multiplication of RB leads to the formation of new lobes of the inclusion
E). A second round of RB enlargement
may follow, yielding more RB, each enclosed in a new lobe. After approximately
20 hours, differentiation of RB back
to EB commences contmporally with the accumulation of developmental forms
within each lobe F) to G).
Differentiation then proceeds, the inclusion and the cell are lysed, and
EB are freed to infect another cell.