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Assorted Emails from different folks and myself expressing the concern we had for Mom receiving Chemo, especially with her having O.I. At this point in time no order of presentation is made.

Dear Dave:

I am sorry to know about your mother. I have not been following the list
very closely lately (mostly due to the overload of nasty messages). Please
update me. Where do they think the problem originates? I am a pediatrician,
and I have worked with children with cancer in the past. Chemo is bad, but
I have seen lots of children surviving thanks to it. Pamidronate is used to
treat hypercalcemia caused by certain types of cancer, it may also help
your mother to prevent fractures and reduce pain. But of course that has to
be determined by the specialists.

Hope this helps.

Best regards,

Horacio Plotkin, M.D.
Clinical Research Coordinator
Genetics Unit
Shriners Hospital for Children
Montreal, Canada

http://geocities.datacellar.net/CapeCanaveral/Lab/3608/
http://www.carone.com/genetics/

----------
From: LIBERTY <libertee@citrus.infi.net>
To: hplotkin@shriners.mcgill.ca
Subject: Mother said to have Cancer
Date: Thursday, June 17, 1999 10:12 AM

Mom is going in for a cat scan today. They seem to be rushing things, which
I don't think is necessarily good, because there are not to many doctors
around here that are familiar with her condition. I really don't even want
her to get a cat scan because of the radiation. I thought maybe the same
results might be attainable with a MRI? With all the x-rays, she has had,
through her lifetime and with radiation having a accumulative effect I can
only surmise that less would be best and preferred!
I am fearful that the radiation accumulated over the years may have
resulted
in this cancer.

I don't believe Mom could take chemo, I know it makes you deadly sick, even
when younger folks take it (I had a nephew who underwent it, and he finally
succumbed (he was 23). The disease is bad enough, but the time you have
left
is made ten times worst because of the chemo.

Right now her general condition seems to be rather good. She can walk with
the assistance of two canes, go out to dinner, go to the race track, etc.
If
this treatment starts that will put an end to that. In other words, she is
able to enjoy herself, pretty much right now and I wish she could maintain
that for as long as possible.

We really haven't been under any doctor's care for OI in probably over
twenty years, no specialists, that is. As I mentioned before there doesn't
seem to be very many doctors in this area that seem to have much of a
handle
on it when it comes to OI.

If anything, I think there should be a meeting of the minds between some
doctors who have had some experience with this cancer and how it effects
people with Mom's disease. I am fearful that the chemo will make her bones
even more brittle. If you could offer any suggestions, it would be greatly
appreciated, and the sooner the better.

Twenty years ago, an emergency room doctor, after looking at some of my
x-rays for a sore hip, had said, that I had bone cancer. Well, although
this is not the same circumstances, it does indicate that the realm of
knowledge in this area is lacking.

If there is anyone with some info helpful, or not, please reply.

Thank You
Dave G. (Liberty)

Dear Dave:

Lymphoma is a malignant disease of the lymph nodes, therefore the rule that
you mention regarding the lymph nodes does not apply. There are two types
of lymphoma, Hodgkin and No-Hodgkin. The differentiation is made with a
biopsy of the lesion.
I have not seen patients with OI going through chemotherapy. As far as I
know, it should not be different than with any other person.

I am sorry I can not be of more help.

Best regards,

Horacio Plotkin, M.D.
Clinical Research Coordinator
Genetics Unit
Shriners Hospital for Children
Montreal, Canada

http://geocities.datacellar.net/CapeCanaveral/Lab/3608/
http://www.carone.com/genetics/



----------
From: LIBERTY <libertee@citrus.infi.net>
To: Horacio Plotkin <hplotkin@shriners.mcgill.ca>
Subject: Mother
Date: Monday, June 21, 1999 11:52 AM

Dear Doctor

I spoke with a Doc. Sunil Gandhi, the physician treating Mom. She and Dad
have an appointment today at 145pm, I will be going to. He told me that she
has lympnoma. If I understood him correctly, he indicated that it wasn't
throughout the body yet? Was mostly in the skin? He said that there is a
good chance for recovery with chemo therapy. But I had always thought that
once it is in your lymnodes you pretty well have had it.

Mom is 78, and he really didn't seem to positive on how chemo would affect
her, not just with her age, but more importantly with O.I. I realize you
are an pediatric physician, but have you seen the effects of chemo on
individuals with O.I.?
Would appreciate anymore imput you could add.

Thanks in Advance

Dave Gregory

 

 

 


 


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citations 1-50 displayed (out of 97 found), page 1 of 2

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Bouabdallah R, et al.           [See Related Articles]
Intensive sequential chemotherapy (ISC 95) with growth factors and blood stem cell support in high-intermediate and high-risk (IPI 2 and IPI 3) aggressive non-Hodgkin's lymphoma: an oligocentric report on 42 patients.
Leukemia. 1999 Jun;13(6):950-6.
[MEDLINE record in process]
PMID: 10360385; UI: 99287130.
Stoppa AM, et al.           [See Related Articles]
Intensive sequential chemotherapy with repeated blood stem-cell support for untreated poor-prognosis non-Hodgkin's lymphoma.
J Clin Oncol. 1997 May;15(5):1722-9.
PMID: 9164178; UI: 97306963.
Gomez H, et al.           [See Related Articles]
Elderly patients with aggressive non-Hodgkin's lymphoma treated with CHOP chemotherapy plus granulocyte-macrophage colony-stimulating factor: identification of two age subgroups with differing hematologic toxicity.
J Clin Oncol. 1998 Jul;16(7):2352-8.
PMID: 9667250; UI: 98329824.
Culine S, et al.           [See Related Articles]
Four-step high-dose sequential chemotherapy with hematopoietic progenitor-cell support as induction treatment for patients with solid tumors.
Ann Oncol. 1997 Oct;8(10):951-6.
PMID: 9402166; UI: 98063758.
Viens P, et al.           [See Related Articles]
High-dose sequential chemotherapy with stem cell support for non-metastatic breast cancer.
Bone Marrow Transplant. 1997 Aug;20(3):199-203.
PMID: 9257887; UI: 97400393.
Shipp MA, et al.           [See Related Articles]
High-dose CHOP as initial therapy for patients with poor-prognosis aggressive non-Hodgkin's lymphoma: a dose-finding pilot study.
J Clin Oncol. 1995 Dec;13(12):2916-23.
PMID: 8523055; UI: 96101608.
Celsing F, et al.           [See Related Articles]
Addition of etoposide to CHOP chemotherapy in untreated patients with high-grade non-Hodgkin's lymphoma.
Ann Oncol. 1998 Nov;9(11):1213-7.
PMID: 9862052; UI: 99079045.
Schiller JH, et al.           [See Related Articles]
A pilot study of short-course, high-dose cytosine arabinoside, etoposide, and cisplatin in refractory, aggressive-histology, non-Hodgkin's lymphomas.
Am J Clin Oncol. 1989 Dec;12(6):502-6.
PMID: 2589231; UI: 90071866.
Weaver CH, et al.           [See Related Articles]
High-dose chemotherapy with BUCY or BEAC and unpurged peripheral blood stem cell infusion in patients with low-grade non-Hodgkin's lymphoma.
Bone Marrow Transplant. 1998 Feb;21(4):383-9.
PMID: 9509973; UI: 98168791.
McMaster ML, et al.           [See Related Articles]
A brief-duration combination chemotherapy for elderly patients with poor-prognosis non-Hodgkin's lymphoma.
Cancer. 1991 Mar 15;67(6):1487-92.
PMID: 1705861; UI: 91159914.
Yalcin S, et al.           [See Related Articles]
VB-CHEP chemotherapy regimen for aggressive non-Hodgkin's lymphomas.
Eur J Haematol. 1998 Oct;61(4):261-5.
PMID: 9820633; UI: 99036519.
Guerci A, et al.           [See Related Articles]
Effect of granulocyte colony-stimulating factor administration in elderly patients with aggressive non-Hodgkin's lymphoma treated with a pirarubicin-combination chemotherapy regimen. Groupe d'Etudes des Lymphomes de l'Adulte.
Ann Oncol. 1996 Nov;7(9):966-9.
PMID: 9006749; UI: 97159409.
Novitzky N, et al.           [See Related Articles]
Treatment of aggressive non-Hodgkin's lymphoma in the elderly.
Am J Hematol. 1995 Jun;49(2):103-8.
PMID: 7771461; UI: 95289375.
Stuart NS, et al.           [See Related Articles]
A new approach to the treatment of advanced high-grade non-Hodgkin's lymphoma--intensive two-phase chemotherapy.
Cancer Chemother Pharmacol. 1988;22(2):141-6.
PMID: 3409445; UI: 88311335.
Younes A, et al.           [See Related Articles]
Paclitaxel plus high-dose cyclophosphamide with G-CSF support in patients with relapsed and refractory aggressive non-Hodgkin's lymphoma.
Br J Haematol. 1998 Dec;103(3):678-83.
PMID: 9858216; UI: 99073927.
Waits TM, et al.           [See Related Articles]
Effective therapy for poor-prognosis non-Hodgkin's lymphoma with 8 weeks of high-dose-intensity combination chemotherapy.
J Clin Oncol. 1993 May;11(5):943-9.
PMID: 7683712; UI: 93253441.
Ohnoshi T, et al.           [See Related Articles]
Brief induction chemotherapy followed by involved-field irradiation for the treatment of localized intermediate- and high-grade non-Hodgkin's lymphoma.
Int J Hematol. 1993 Jan;57(1):61-6.
PMID: 7682860; UI: 93237508.
Martelli M, et al.           [See Related Articles]
P-VABEC: a prospective study of a new weekly chemotherapy regimen for elderly aggressive non-Hodgkin's lymphoma.
J Clin Oncol. 1993 Dec;11(12):2362-9.
PMID: 7504091; UI: 94065867.
Weaver CH, et al.           [See Related Articles]
High-dose chemotherapy and peripheral blood stem cell infusion in patients with non-Hodgkin's lymphoma: results of outpatient treatment in community cancer centers.
Bone Marrow Transplant. 1997 Nov;20(9):753-60.
PMID: 9384477; UI: 98044133.
Nademanee A, et al.           [See Related Articles]
Results of high-dose therapy and autologous bone marrow/stem cell transplantation during remission in poor-risk intermediate- and high-grade lymphoma: international index high and high-intermediate risk group.
Blood. 1997 Nov 15;90(10):3844-52.
PMID: 9354650; UI: 98022775.
Bergmann L, et al.           [See Related Articles]
Vincristine, doxorubicin, cyclophosphamide, prednisone and etoposide (VACPE) in high-grade non-Hodgkin's lymphoma--a multicenter phase II study.
Ann Oncol. 1995 Dec;6(10):1019-24.
PMID: 8750155; UI: 96343311.
McMaster ML, et al.           [See Related Articles]
Results of treatment with high intensity, brief duration chemotherapy in poor prognosis non-Hodgkin's lymphoma.
Cancer. 1991 Jul 15;68(2):233-41.
PMID: 1712662; UI: 91300410.
Dorigo A, et al.           [See Related Articles]
Lomustine, etoposide, methotrexate and prednisone (LEMP) therapy for relapsed and refractory non-Hodgkin's lymphoma.
Eur J Haematol. 1993 Jan;50(1):37-40.
PMID: 8436213; UI: 93170459.
Gomez GA, et al.           [See Related Articles]
Primary chemotherapy for localized non-Hodgkin's lymphomas with diffuse histologic characteristics. Preliminary report of a prospective study.
Arch Intern Med. 1986 Sep;146(9):1785-8.
PMID: 3489446; UI: 86322249.
Wilson WH, et al.           [See Related Articles]
Phase II and dose-escalation with or without granulocyte colony-stimulating factor study of 9-aminocamptothecin in relapsed and refractory lymphomas.
J Clin Oncol. 1998 Jul;16(7):2345-51.
PMID: 9667249; UI: 98329823.
Stamatoullas A, et al.           [See Related Articles]
Ifosfamide, etoposide, cytarabine, and methotrexate as salvage chemotherapy in relapsed or refractory aggressive non-Hodgkin's lymphoma.
Cancer. 1996 Jun 1;77(11):2302-7.
PMID: 8635099; UI: 96224897.
Singer JM, et al.           [See Related Articles]
VAPEC-B chemotherapy in the treatment of aggressive non-Hodgkin's lymphoma: a retrospective analysis of 45 patients.
Clin Oncol (R Coll Radiol). 1995;7(6):366-70.
PMID: 8590697; UI: 96163601.
Pendleton N, et al.           [See Related Articles]
A six-drug regimen (MAPECO) for intermediate or high-grade non-Hodgkin's lymphoma.
Acta Oncol. 1994;33(5):513-8.
PMID: 7917364; UI: 95000738.
Zinzani PL, et al.           [See Related Articles]
Intensive chemotherapy regimen in high-grade non Hodgkin's lymphomas.
Tumori. 1987 Apr 30;73(2):121-6.
PMID: 3576707; UI: 87207218.
Sweetenham JW, et al.           [See Related Articles]
Intensive weekly combination chemotherapy for patients with intermediate-grade and high-grade non-Hodgkin's lymphoma.
J Clin Oncol. 1991 Dec;9(12):2202-9.
PMID: 1720454; UI: 92071757.
Verdonck LF, et al.           [See Related Articles]
Salvage therapy with ProMACE-MOPP followed by intensive chemoradiotherapy and autologous bone marrow transplantation for patients with non-Hodgkin's lymphoma who failed to respond to first-line CHOP.
J Clin Oncol. 1992 Dec;10(12):1949-54.
PMID: 1453209; UI: 93085398.
Schwartzberg LS, et al.           [See Related Articles]
Sequential treatment including high-dose chemotherapy with peripheral blood stem cell support in patients with high-risk stage II-III breast cancer: outpatient administration in community cancer centers.
Am J Clin Oncol. 1998 Oct;21(5):523-31.
PMID: 9781614; UI: 98452874.
Schenkein DP, et al.           [See Related Articles]
A phase II multicenter trial of high-dose sequential chemotherapy and peripheral blood stem cell transplantation as initial therapy for patients with high-risk non-Hodgkin's lymphoma.
Biol Blood Marrow Transplant. 1997 Oct;3(4):210-6.
PMID: 9360783; UI: 98025258.
Koc H, et al.           [See Related Articles]
Use of high-dose chemotherapy plus granulocyte colony-stimulating factor for the salvage of refractory or resistant-relapse lymphoma patients without stem cell support.
Acta Haematol. 1997;98(3):136-9.
PMID: 9352743; UI: 98014109.
Gabarre J, et al.           [See Related Articles]
Chemotherapy combined with zidovudine and GM-CSF in human immunodeficiency virus-related non-Hodgkin's lymphoma.
Ann Oncol. 1995 Dec;6(10):1025-32.
PMID: 8750156; UI: 96343312.
Long GD, et al.           [See Related Articles]
Multiple cycles of high dose chemotherapy supported by hematopoietic progenitor cells as treatment for patients with advanced malignancies.
Cancer. 1995 Sep 1;76(5):860-8.
PMID: 8625190; UI: 96223113.
Niitsu N, et al.           [See Related Articles]
Combination chemotherapy with COP-BLAM III for intermediate and high-grade non-Hodgkin's lymphoma.
Int J Hematol. 1994 Jul;60(1):71-8.
PMID: 7522616; UI: 95002809.
Itoh K, et al.           [See Related Articles]
Toxicity and efficacy of ifosfamide, carboplatin and etoposide (modified ICE) as a salvage chemotherapy in Japanese patients with relapsed or refractory aggressive non-Hodgkin's lymphoma.
Int J Hematol. 1998 Dec;68(4):431-7.
PMID: 9885442; UI: 99102828.
Hohaus S, et al.           [See Related Articles]
Efficacy and toxicity of sequential high-dose therapy with peripheral blood stem cell support in patients with high-risk breast cancer.
Semin Oncol. 1998 Apr;25(2 Suppl 4):7-11; discussion 45-8.
PMID: 9578056; UI: 98237166.
Tallman MS, et al.           [See Related Articles]
High-dose chemotherapy, autologous bone marrow or stem cell transplantation and post-transplant consolidation chemotherapy in patients with advanced breast cancer.
Bone Marrow Transplant. 1997 Nov;20(9):721-9.
PMID: 9384473; UI: 98044129.
Advani S, et al.           [See Related Articles]
Preliminary report of an intensified, short duration chemotherapy protocol for the treatment of pediatric non-Hodgkin's lymphoma in India.
Ann Oncol. 1997 Sep;8(9):893-7.
PMID: 9358941; UI: 98023846.
Smith GM, et al.           [See Related Articles]
A phase I trial to assess the value of recombinant human granulocyte colony stimulating factor (R-MeTHuG-CSF, filgrastim) in accelerating the dose rate of chemotherapy for intermediate and high-grade non-Hodgkin's lymphoma (NHL). The Central Lymphoma Group.
Hematol Oncol. 1996 Dec;14(4):193-201.
PMID: 9267465; UI: 97412822.
Janicek M, et al.           [See Related Articles]
Early restaging gallium scans predict outcome in poor-prognosis patients with aggressive non-Hodgkin's lymphoma treated with high-dose CHOP chemotherapy.
J Clin Oncol. 1997 Apr;15(4):1631-7.
PMID: 9193363; UI: 97336616.
Koziner B, et al.           [See Related Articles]
NHL-3 protocol. Six-drug combination chemotherapy for non-Hodgkin's lymphoma.
Cancer. 1984 Jun 15;53(12):2592-600.
PMID: 6547072; UI: 84205213.
Guglielmi C, et al.           [See Related Articles]
Sequential combination chemotherapy of high-grade non-Hodgkin's lymphoma with 5-fluorouracil, methotrexate, cytosine-arabinoside, cyclophosphamide, doxorubicin, vincristine, and prednisone (F-MACHOP).
Cancer Invest. 1987;5(3):159-69.
PMID: 3651863; UI: 88001609.
Ibrahim EM, et al.           [See Related Articles]
Combination chemotherapy only for stage II non-Hodgkin's lymphoma.
Eur J Cancer Clin Oncol. 1986 Feb;22(2):199-203.
PMID: 2422039; UI: 86192604.
Brice P, et al.           [See Related Articles]
Aggressive non Hodgkin lymphoma in the elderly. A retrospective study of 72 patients with clinical features and treatment.
Nouv Rev Fr Hematol. 1990;32(2):153-7.
PMID: 2377447; UI: 90332387.
Zuckerman KS, et al.           [See Related Articles]
Chemotherapy of intermediate- and high-grade non-Hodgkin's lymphomas with a high-dose doxorubicin-containing regimen.
J Clin Oncol. 1990 Feb;8(2):248-56.
PMID: 2299368; UI: 90132831.
Jakacki RI, et al.           [See Related Articles]
Feasibility of sequential high-dose chemotherapy and peripheral blood stem cell support for pediatric central nervous system malignancies.
Med Pediatr Oncol. 1997 Dec;29(6):553-9.
PMID: 9324343; UI: 97464522.
Stamatoullas A, et al.           [See Related Articles]
Peripheral blood stem cell transplantation for relapsed or refractory aggressive lymphoma in patients over 60 years of age.
Bone Marrow Transplant. 1997 Jan;19(1):31-5.
PMID: 9012928; UI: 97165167.

 

Strahlenther Onkol 1994 Nov;170(11):665-7

 

[Osteogenesis imperfecta and breast carcinoma. A case study of radiobiological interest].

[Article in German]

 

Bohler FK, Rhomberg W

Landeskrankenhaus Feldkirch, Abteilung fur Radioonkologie, Osterreich.

PURPOSE: Osteogenesis imperfecta (OI) is an inherited disorder of connective tissue with abnormal quality and/or quantity of type 1 collagen. The frequency of the association of OI and breast cancer as well as the frequency of radiation induced side-effects in patients with OI are not known. Certain diseases with widespread collagen alterations such as systemic lupus erythematodes or dermatomyositis--although not exactly comparable to congenital OI--carry a high risk for radiation injuries in case of irradiation with normal doses. The report of a patient with osteogenesis imperfecta type I and postmastectomy irradiation might therefore be of some radiobiological interest. METHODS: Report of a 46-year-old women with OI type I and breast cancer with a 14-year follow-up time after mastectomy and external beam irradiation. RESULTS: During all the follow-up time there was no radiation injury in this patient with OI type I and breast cancer. CONCLUSION: Mostly it is not possible to draw a valid conclusion from a case report, but with this experience the combination of OI type I and radiotherapy seems not to cause unusual radiation injury. Contrary to OI of type II and III, in the majority of the cases of OI type I there is a normal quality, but diminished quantity of collagen type I. This could be one of the possible reasons for the absence of adverse radiation effects. Finally, it might be of interest, that the gene-locus of the two alpha-1(I)-chains of collagen type I is situated at chromosome 17q21-22, where also the location of the "breast-cancer gene" is supposed to be. A genetic examination was, unfortunately, refused by the patient.

Publication Types:

Review

  • Review of reported cases

PMID: 7974182, UI: 95064491

 

Am J Ind Med 1999 Jul;36(1):155-8

 

Dave, the next one may be significant as it concerns exposure, I am assuming this includes exposure to x-rays, and increases in cancer of health professionals.  May be a link to your mom's years of x-rays and possible cancer?

 

Cancer mortality in health and science technicians.

 

Burnett C, Robinson C, Walker J

Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. CAB9@CDC.GOV

[Medline record in process]

BACKGROUND: Nearly one million U.S. women are employed as health or science technicians with various chemical and biological exposures, but few studies have looked at their health outcomes. METHODS: Using 1984-1995 mortality data with coded occupation information, we calculated race- and age-adjusted proportionate cancer mortality ratios (PCMRs) and 95% confidence intervals for two age groups for black and white women with occupations of clinical laboratory (CLT), radiologic, and science technician. RESULTS: For CLTs, the PCMRs for breast cancer were borderline significantly elevated. The PCMRs for leukemia were significantly elevated, particularly for myeloid leukemia. Radiologic technicians had no significantly elevated PCMRs. Science technicians had significantly elevated PCMRs for non-Hodgkin's lymphoma and multiple myeloma in the younger age group. DISCUSSION: The elevated risks for lymphatic and hematopoietic neoplasms in CLTs and science technicians may be associated with occupational exposures.

PMID: 10361601, UI: 99289952

Am J Ind Med 1999 Jul;36(1):60-9

 

Occupational, environmental, and life-style factors associated with the risk of hematolymphopoietic malignancies in women.

 

Miligi L, Seniori Costanini A, Crosignani P, Fontana A, Masala G, Nanni O, Ramazzotti V, Rodella S, Stagnaro E, Tumino R, Vigano C, Vindigni C, Vineis P

Epidemiology Unit, Center for Study and Prevention of Cancer, Az. Ospedaliera Careggi, Florence, Italy. epid@ats.it

[Medline record in process]

BACKGROUND: The etiology of lymphomas, leukemias, and multiple myeloma is still largely unknown. The known risk factors (ionizing radiation, solvent exposure, pesticide exposure, immunosuppression) explain only a small proportion of the cases that occur. METHODS: We conducted a multicenter population-based case-control study on hematolymphopoietic malignancies in Italy and interviewed 2,011 women (1,183 cases and 828 controls). RESULTS: There was a suggestion of a positive association between smoking and the risk of non-Hodgkin's lymphoma + chronic lymphocytic leukemia. A slight increased risk of leukemias was observed among women using permanent hair dye. Housewives were at increased risk for leukemia and multiple myeloma. The risk of non-Hodgkin's lymphomas + chronic lymphocytic leukemia, leukemias, multiple myeloma, and Hodgkin's disease increased among women employed as hairdressers and textile workers. Teachers were at increased risk for non-Hodgkin's lymphomas + chronic lymphocytic leukemia, leukemias, and Hodgkin's disease. CONCLUSIONS: These results confirm previous associations and may provide additional clues to some determinants of hematolymphopoietic malignancies in women.

PMID: 10361588, UI: 99289939

Leukemia 1999 Jun;13(6):950-6

 

Intensive sequential chemotherapy (ISC 95) with growth factors and blood stem cell support in high-intermediate and high-risk (IPI 2 and IPI 3) aggressive non-Hodgkin's lymphoma: an oligocentric report on 42 patients.

 

Bouabdallah R, Stoppa AM, Rossi JF, Lepeu G, Coso D, Xerri L, Ladaique P, Chabannon C, Blaise D, Bardou VJ, Alzieu C, Gastaut JA, Maraninchi D

Department of Hematology, Institut J Paoli-I Calmettes, Regional Cancer Center-Universite de la Mediterranee, Marseille, France.

[Medline record in process]

We previously reported feasibility and efficacy of a monocentric pilot study of intensive sequential chemotherapy (ISC) in poor-risk aggressive non-Hodgkin's lymphoma (NHL) in patients < 60 years. To validate these results on a large cohort of patients, we designed a new and oligocentric study. After a COP (cyclophosphamide (Cy), vincristine (Vcr), prednisone (Pred) debulking, patients received four courses of high-dose CHOP (Cy, doxorubicin (Doxo), Ver, Pred), with the addition of etoposide and cisplatin during the two last courses. G-CSF was delivered after each cycle, and peripheral blood stem cells (PBSC) were used to support the two last cycles. Total duration of chemotherapy was 13 weeks, with a planned dose-intensity (DI) of 1420 mg/m2/week and 23 mg/m2/week for Cy and Doxo, respectively. Radiotherapy (involved fields) was then delivered for patients with node size > or = 5 cm at diagnosis. Forty-two patients were enrolled in this study; 36 completed the treatment and received 75% or more of the planned DI for both Cy and Doxo. Median duration of grade 4 neutropenia was 14 days (range, 2 to 28) for the regimen as a whole, and median duration of rehospitalization for febrile neutropenia was 18 days (range, 4 to 41). Overall response rate was 83%, with 29 patients (69%) in complete response (CR). Six patients failed to respond and one died of toxicity. With a median follow-up of 22.5 months (range, 10 to 42), the 3-year event-free survival (EFS) is 55% (95% CI, 39-71), while disease-free survival (DFS) is 79% (95% CI, 63-95). Ambulatory ISC is accessible and feasible in an oligocentric study. PBSC allow repeated delivery of high-dose chemotherapy cycles, and result in encouraging CR, EFS, and DFS rates for poor-risk aggressive NHL's patients.

PMID: 10360385, UI: 99287130

 

 

THE E-MAIL COMES AT MY HOME , I DO NOT KNOW THE RESULT OFF HAND, WE WILL DISCUSS AT  HER NEXT VISIT.
-----Original Message-----
From: LIBERTY <libertee@citrus.infi.net>
To: Doc. Gandhi <sgandhi@hitter.net>
Date: Wednesday, June 23, 1999 9:20 PM
Subject: Mother

Hi Doctor
 
Hope your feeling well today. This is Dave Gregory, you will be treating my mother Rita, in the near future. I was writing to double check on her heart's ability to  withstand chemo? Does it appear to be OK?
 
Thanks
 
Dave Gregory

 

David, it was nice talking to you.  I hope all goes well.
 
J. Bennett
----- Original Message -----
From: LIBERTY
Sent: Friday, August 06, 1999 9:14 PM
Subject: MOTHER

 
Dear Dr. Bennett
 
 
My mother Rita Gregory started Chemo about three weeks ago. Her next Chemo session is this coming Monday. She has been diagnosed with non-Hodgkin's lymphoma. She has already lost all her hair. She is 77 years old. Dr. Gandhi from Lecanto is treating her. She has osteogensis imperfecta.
 
I wanted her to get a second opinion and Dr. Gandhi office was requested for her medical information. He telephoned my parents the day of the request and scared the hell out of them. Paraphrasing my folks, he told them that it didn't manner where she went, including Moffett or any other cancer treatment facility the diagnose would be the same and that she needed to receive treatments right away. So my parents immediately dismissed my efforts to get a second opinion.
 
Whether this may be true, or not, I feel that it was a totally unethical move to make!
 
I have read your article (990323.htm-The Complex Issue of Lymphoma) and it would seem to indicate that there are many variables in regards to this disease and the appropriate treatment thereof. Do you believe it would be advisable for my mother to still get a second opinion? Or, should I just let the manner rest?
 
Sincerely
 
David J. Gregory
352-628-0680

 

From: LIBERTY To: Kat ; Zac ; judith severy ; Jeff ; Bobby ; Bill & Shelly Hill ; Bill & Helen ; Aline & Corky Subject: MOM Date: Thursday, September 23, 1999 7:48 PM Mom is feeling a lot better than 3 or 4 weeks ago. Guess she won't be getting anymore chemo, she didn't tolerate it very well. She has a new electric wheelchair which she enjoys very much. She enjoys getting email so if you send me some send copies to her, or vise versa. That computer over at her house is pretty temperamental so I am the one who has to operate it. But anyhow, she enjoys getting it there and asks me to check it for her when I am there. Aunt Helen and Uncle Bill, I know you guys were there just a few days ago, thought I would include you in this email to save myself a little time. Glad you had a safe trip home, it was good seeing you. If anyone would like to leave a voice mail for me the number is below, it's a toll free #. Check out our revamped site. Bye for now Dave ps Mom & Dad's email address is geronimo@citrus.infi.net Please check out our all in one, ONE-STOP ONLINE SHOPPING EXPERIENCE, INCLUDING CHAT PAGES AND MORE! http://northernexposurerevisited.virtualave.net/ Call our new toll free voice mail number: 1-888-392-4832 Extension: 335-483-7437 which spells deliveries! There is also the option to fax us via this number, listen to the directions.

From: LIBERTY To: Doc. Gandhi Subject: MOTHER Date: Sunday, August 29, 1999 8:13 PM Dr. Gandhi My mother spent an unrest weekend. I fear she may have fractured more ribs. She has eaten very little. It is difficult even moving her in bed. She has lost all her strength. I have kept a close watch on her temperature and she hasn't had any. Yet she continues to cough, causing her great discomfort. If she does not regain some strength I can't possible see how she could withstand another chemo session. David Gregory

From: LIBERTY To: Subject: Re: MOM Date: Monday, September 27, 1999 8:43 AM ----- Original Message ----- From: To: Sent: Sunday, September 26, 1999 7:35 PM Subject: Re: MOM > In a message dated 9/23/99 8:49:28 PM Eastern Daylight Time, > libertee@citrus.infi.net writes: > > << > Mom is feeling a lot better than 3 or 4 weeks ago. Guess she won't be > getting anymore chemo, she didn't tolerate it very well. She has a new > electric wheelchair which she enjoys very much. > > Hey! I'm glad to here that she is feeling better. Was her chemo over already? > I'm glad to hear she likes her wheelchair. I didn't realize that she had to > use one. When did she start that? She really went downhill with the chemo, she could barely turn over in bed only after two treatments, don't know what is next, she may begin it again, hopefully with a different doctor. This one didn't take into account her prior medical condition. She enjoys getting email so if you send me some send copies to her, or vise > versa. That computer over at her house is pretty temperamental so I am the > one who has to operate it. But anyhow, she enjoys getting it there and asks > me to check it for her when I am there. > > I'll send her some email. > > ps Mom & Dad's email address is geronimo@citrus.infi.net > > Where has time gone??? Have I written to you since our grandbaby was born? > Kyle Jackson Campbell, 20 Aug. 1999. Don't think I heard about the grandbaby, Congratulations! > > Well, I'm off to do homework for my computer class. Talk to you later. > Kathy > >

From: LIBERTY To: Subject: Re: Mother Date: Tuesday, August 10, 1999 6:47 PM Hi folks Mom had a pretty good day today. She had a Chemo session yesterday. She has to go back every day to have a dose of antibiotics, her immune system is way down. I had to go to Orlando airport last night, got back 3am. Got to go to Tampa tomorrow (Wed. morning at 3am). I got Mom some of those face masks to try and keep the germs away from her. It's early, but I am beat, so I'll talk to you later Dave ----- Original Message ----- From: To: Sent: Tuesday, August 10, 1999 5:16 PM Subject: Mother > Just wondered how your mother is doing.. Wasnn't she suppose to have her > second treatment this week. How is Bernard holding up thru all this. > Had oil tank filled Monday and turned on furnace this morning for a minute to > take off the chill. Good weather to get work done!! > Stopped at Severys today but they weren;t home MAKE a few pit stops every > now and then. They have quite a little going on with them too > > > > Aline > The Vermont Socialite >

From: Liberty To: jeffrey c. hill Subject: Re: rita Date: Sunday, August 08, 1999 12:04 PM ----- Original Message ----- From: jeffrey c. hill To: Sent: Saturday, August 07, 1999 9:41 PM Subject: rita > david, i will be to visit your mother on the 23rd of august. can you verify that she will be there? As far as I know, she will be there. She takes a second dose of Chemo tomorrow. They don't go to far away from the house. > > is there anything i can bing to comfort her. Just yourself. Dave > > jeff > > > Don't forget to sign up for FREE e-mail on > http://www.medmail.com - The E-mail > service for the Medical Community >

From: Liberty To: judith severy Subject: Re: severy Date: Wednesday, September 15, 1999 8:48 AM Hi Uncle Charles & Aunt Lorraine Mom didn't have the treatment Monday, thought she was coming down with a cold, not sure, today (Wednesday) she is suppose to go back out there I guess. She is 100% better than she was when you all were down here. She is moving well and walking with aid, her stomach has even gone down. Unfortunately, I fear she will just go back the other way when she begins chemo again. She is schedule to go to another Doctor on Thursday. I have done a lot of work setting up appointments and getting records, but it usually gets all screwed up with the folks canceling and changing their minds on things. I have no idea if they will make this appointment. I am sorry you had such a lousy trip back up to VT. That's it for now! Thank goodness that storm missed us, we were pretty worried for awhile. Dave ----- Original Message ----- From: judith severy To: Sent: Monday, September 13, 1999 12:34 AM Subject: severy > Good morning from the north. David your mother take the treatment > yesterday? and how did your father make out with his appt. We have been > watching the storm on the tv and hope that it pass you folks you dont > need it at this time. Talk with Aline Douglas and they said they might > have to make a fast trip down if it hits near them. Well David let us > know how things are going Uncle Charles and Aunt Lorraine > >

From: LIBERTY To: Jeff Subject: Rita Date: Sunday, September 12, 1999 8:43 AM Hi Jeff How are you doing? Things are somewhat better here than a few weeks ago. Mom is much stronger and feels 100% better. But she has not had another dose of Chemo for about 5 or 6 weeks. She is walking with aid and it appears that her fractures are healing. The x-rays didn't show the fractures, but the bone scan did. She is suppose to go for another Chemo tomorrow. She is dreading it, so am I. She seems more like her old self. I can't stand Gandhi, I am not going to have anything to do with him. When Mom was going through the ordeal of a few weeks back and she was in the hospital. He told me he had called in all the specialists, pain management doctor and bone specialist. These are individuals I believe he should have called in prior to treatment, not after the fact (Mom's deteriorating condition) There should have been some sort of consultation for a consensus on the best possible treatment and how it would effect Mom considering her bone condition! When I asked Gandhi about further Chemo treatment he stated he did not think she could get anymore at that time because she could not even stand up?!!? Now that Mom is feeling better he wants to start the same treatment regiment as before! I would think the results will be similar. Mom could only stay in the hospital for a week under the circumstances and he did get her into a nursing home for rehab (which Medicare would have paid for two weeks). Mom threw a fit, she was all right when she first got there and we were there with her, but when we went home it was about an hour when we started getting calls with her being extremely distraught. She only spent one night there. Dad went and picked her up the next morning. Aunt Lorraine, Aunt Lorenza and Uncle Charles went back on Sept. 9. Mom was glad to see them. I led them to and from the airport. Uncle Charles said he would have never found their way. Well, guess that's the lowdown for now. Hope things are well on the farm! Dave Please check out our all in one, ONE-STOP ONLINE SHOPPING EXPERIENCE, INCLUDING CHAT PAGES AND MORE! http://northernexposurerevisited.virtualave.net/ Call our new toll free voice mail number: 1-888-392-4832 Extension: 335-483-7437 which spells deliveries! There is also the option to fax us via this number, listen to the directions.

Ocala Oncology July 15, 1999

Drs. Wright, Cartwright & Reynolds

My mother, Rita Gregory, is scheduled to have a catheter implanted tomorrow (7/16/99) at Citrus Memorial Hospital. She is 77 years old and has Osteogenesis Imperfecta. Her Chemo is scheduled to begin on the 19th (Monday). She has been diagnosed with non-Hodgins, aggressive lymphoma.

I am concerned with how Chemo will effect her precondition of Osteogenesis Imperfecta? Also, I would like to know how fast this disease would work? She bruises and cuts very easily, and this is of concern to me also.

If you could schedule an appointment for her as soon as possible it would be greatly appreciated.

My phone number is 352-628-6762 David Gregory

My Mother’s number is 352-628-2213 Rita Gregory

Please call us asap!

Thank You

 

The fax number for Cancer & Blood Disease Center, in Lecanto is 352-746-6333.

 

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