Lyme Disease Hall of Shame
On the authors of "Long-term Outcomes of Persons With Lyme Disease", JAMA, 2 Feb 2000
Lyme disease is a serious bacterial infection caused by a tick bite and
affects humans and animals.
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Table of Contents
Elyse G. Seltzer, MD
Michael A. Gerber, MD
Matthew L. Cartter, MD
Kimberly Freudigman, PhD
Eugene D. Shapiro, MD
Back to the Lyme Disease Hall of Shame home page
For more information on Lyme disease
The following information was found in the National Institutes of
Health (NIH), National Library of Medicine (NLM), MEDLINE database
pertaining to the five authors of:
Long-term Outcomes of Persons With Lyme Disease
JAMA, Vol. 283, No. 5, 2 February 2000
The following summaries with complete texts of all NLM MEDLINE citations
for each of the five authors above, related to Lyme disease, can be
found at the following web page:
The Lyme Disease Hall of Shame
Elyse G. Seltzer, MD
------------------------------------
mailto:elyse.seltzer@yale.edu
Yale University School of Medicine, New Haven
Dr Seltzer is now with SmithKline Beecham Pharmaceuticals.
The following link was used to find all MEDLINE citations and abstracts pertaining
to Lyme disease with Seltzer as one of the authors:
MEDLINE - Seltzer AND Lyme disease - 2 citations found on 2 Feb 00
Summaries of all MEDLINE citations on Lyme disease for Elyse G. Seltzer, MD
1 - "...prognosis is excellent for children with Lyme disease who have
been treated with standard antimicrobial regimens".
2 - Title: Misdiagnosis of Lyme disease: when not to order serologic
tests. [no abstract available.]
Michael A. Gerber, MD
------------------------------------
University of Connecticut Health Center
263 Farmington Avenue, Farmington, CT 06030
(860) 679-2000
The following link was used to find all MEDLINE citations and abstracts pertaining
to Lyme disease with Gerber as one of the authors:
MEDLINE - Gerber AND Lyme disease - 22 citations found on 2 Feb 00
Summaries of all MEDLINE citations on Lyme disease for Michael A. Gerber, MD
[Note: Items 2, 6, 7, 18, and 22 were by a different Gerber.]
1 - TITLE: Lyme disease vaccine. [No abstract available.]
3 - "...the prognosis for children with Lyme arthritis who are treated
with appropriate antimicrobial therapy is excellent."
4 - TITLE: Lyme disease and facial nerve palsy [editorial] [No abstract
available.]
5 - "The prognosis is excellent for those with early Lyme disease who
are treated promptly with conventional courses of antimicrobial agents."
8 - "Lyme disease is an important health problem in school-aged children
living in southeastern Connecticut." COMMENT: And this "brillant" fact
was determined in 1995, 20 years after Lyme disease was discoverd in
southeastern Connecticut - in children - who were misdiagnosed as having
juvenile rheumatoid arthritis - by rheumatiods.
9 - TITLE: Appropriateness of serologic tests and parenteral antibiotic
therapy for patients with presumed Lyme disease. [No abstract
available.]
10 - "The IgM rOspC ELISA is a convenient, readily automated, easily
standardized serologic test that is significantly more sensitive for the
diagnosis of early Lyme disease than either WC ELISA or immunoblot
assay."
11 - "The risk of acquiring either Lyme disease or babesiosis from a
blood transfusion in Connecticut is very low."
12 - "We conclude that congenital neuroborreliosis is either not
occurring or is occurring at an extremely low rate in areas endemic
for Lyme disease." COMMENT: Well, which is it?
13 - "A telephone interview program 1 to 6 years after the initial
episode of Lyme disease revealed that none of the patients had evidence
of carditis, arthritis, or neurologic complications attributable to Lyme
disease." COMMENT: Another one of those "scientific" phone surveys.
14 - "The existence of a form of early Lyme disease characterized by a
flu-like illness without erythema migrans is controversial. ...The
existence of a flu-like illness without erythema migrans of early
Lyme disease has been clearly established." COMMENT: The existence of
persisting or relapsing Lyme disease seems to be controversial for some
researchers. ........
15 - "Even in an area in which Lyme disease is endemic, the risk of
infection with B. burgdorferi after a recognized deer-tick bite is so
low that prophylactic antimicrobial treatment is not routinely
indicated." COMMENT: Lots of controversey on this paper evidenced by
the number of comments to it. See all comments at:
Antimicrobial Prophylaxis after Tick Bites, NEJM 1993; 328: 1418-1420
For more on prophylactic antibiotic treatment of tick bites, see:
Antibiotic Prophylaxis After Tick Bite For Prevention Of Lyme Disease -
An Annotated Bibliography
16 - "To determine if antibodies to Borrelia burgdorferi persist after
antibiotic treatment, we recalled 32 patients with Lyme disease from a
primary care practice a mean of 16 months after treatment and analyzed
initial and follow-up serum samples by ELISA and immunoblot assays.
...Nine of the 32 patients had persistent or recurrent symptoms, and
ELISA and immunoblot were not helpful for identifying these nine
patients." COMMENT: But, do these researchers believe the patients
still have Lyme disease?
17 - TITLE: Diagnosis of Lyme disease in children. [No abstract
available.]
19 - TITLE: False positive serologic tests for Lyme disease after
varicella infection [letter] [No abstract available.]
20 - "There is a considerable risk of babesial infection among residents
of the Connecticut mainland who are seropositive for Lyme disease, a
risk that appears to have remained constant over the past 5 years."
[Note: Gerber M assumed to be Gerber MA.]
21 - TITLE: Lyme disease and pregnancy. [No abstract available.]
Matthew L. Cartter, MD
------------------------------------
(860)509-7994
Connecticut Department of Public Health
Epidemiology
410 Capitol Avenue
P.O. Box 340308
Hartford, CT 06134-0308
Phone: (860)509-8000
The following link was used to find all MEDLINE citations and abstracts pertaining
to Lyme disease with Cartter as one of the authors:
MEDLINE - Cartter AND Lyme disease - 10 citations found on 2 Feb 00
Summaries of all MEDLINE citations on Lyme disease for Matthew L. Cartter, MD
COMMENT: I mean, who would have thunk?
Who would have thunk that...
1 - "The incidence of Lyme disease was positively correlated with tick
abundance...". Furthermore, "...the number of I. scapularis ticks
infected by B. burgdorferi ...was highly correlated with the incidence
of Lyme disease in Connecticut."
Who would have thunk that the...
2 - Incidence of Lyme disease is dependent on where one resides.
Who would have thunk that...
3 - One's prevention practices regarding Lyme disease are dependent on
what one knows about Lyme disease.
Who would have thunk that...
4 - "Physician underreporting of Lyme disease underestimates the
public health impact of Lyme disease."
Who would have thunk that...
5 - "Lyme disease is an important health problem in school-aged children
living in southeastern Connecticut." COMMENT: And this "brillant" fact
was determined in 1995, 20 years after Lyme disease was discoverd in
southeastern Connecticut - in children - who were misdiagnosed as having
juvenile rheumatoid arthritis - by rheumatiods.
6 - "Borrelia burgdorferi is widely distributed in I. scapularis
populations in Connecticut."
7 - Title: Reinfection with Borrelia burgdorferi. [No abstract
available.]
Who would have thunk that...
8 - "Students who believed a specific behavior was preventive were 3-6
times more likely than others to practice that behavior. Schools in
endemic areas should educate students about Lyme disease."
9 - Title: Lyme disease and pregnancy. [No abstract available.]
Who would have thunk that...
10 - "Continued reporting of cases with supporting clinical information
is needed to improve Lyme disease surveillance and establish disease
trends."
Kimberly Freudigman, PhD
------------------------------------
mailto:kimberly.freudigman@yale.edu
office_phone: (203)688-4549
Yale University School of Medicine
Department of Pediatrics
Yale University School of Medicine
333 Cedar St, New Haven, CT 06520-8064
The following link was used to find all MEDLINE citations and abstracts pertaining
to Lyme disease with Freudigman as one of the authors:
MEDLINE - Freudigman K - 0 citations found on 2 Feb 00
Summaries of all MEDLINE citations on Lyme disease for Kimberly Freudigman, PhD
0
Complete text of all MEDLINE citations on Lyme disease for Kimberly Freudigman, PhD
0
Link for all NLM MEDLINE citations by Freudigman K:
MEDLINE - Freudigman K - 5 citations found on 2 Feb 00
Eugene D. Shapiro, MD
------------------------------------
mailto:eugene.shapiro@yale.edu
office_phone: (203)688-4518
Yale University School of Medicine
Department of Pediatrics
Yale University School of Medicine
333 Cedar St, New Haven, CT 06520-8064
The following link was used to find all MEDLINE citations and abstracts pertaining
to Lyme disease with Shapiro as one of the authors:
MEDLINE - Shapiro AND Lyme disease - 18 citations found on 2 Feb 00
Summaries of all MEDLINE citations on Lyme disease for Eugene D. Shapiro, MD
[Note: Items 1, 14, and 18 were by a different Shapiro, but item 5 by
Shapiro EE was assumed to be a typo]
2 - "...the prognosis for children with Lyme arthritis who are treated
with appropriate antimicrobial therapy is excellent." COMMENT: See no.
7 where Shapiro used the term "standard antimicrobial regimens" in the
same context.
3 - Title: Lyme disease. [No abstract available.]
4 - Title: Tick-borne diseases. [No abstract available.]
5 - Title: Guillain-Barre syndrome in a child with serologic evidence of
Borrelia burgdorferi infection. [No abstract available.] [Note: Shapiro
EE assumed to be a typo.]
6 - Title: Lyme disease and facial nerve palsy [editorial] [No abstract
available.]
7 - "...prognosis is excellent for children with Lyme disease who have
been treated with standard antimicrobial regimens".
8 - "About 90 percent of children with Lyme disease present with
erythema migrans, which is an early stage of the disease. The prognosis
is excellent for those with early Lyme disease who are treated promptly
with conventional courses of antimicrobial agents."
9 - Title: Misdiagnosis of Lyme disease: when not to order serologic
tests. [no abstract available.]
10 - "Careful prospective studies have found that nearly 90% of children
with Lyme disease have erythema migrans. Although there has been great
concern about congenital Lyme disease, no data suggest that it is a
significant problem, nor has transmission of Lyme disease through breast
milk been documented. Virtually all children will respond well to
treatment for any stage of Lyme disease. Misdiagnosis is the most common
reason for treatment failure. Long-term follow-up studies indicate that
the prognosis for children with Lyme disease is excellent."
11 - "The IgM rOspC ELISA is a convenient, readily automated, easily
standardized serologic test that is significantly more sensitive for the
diagnosis of early Lyme disease than either WC ELISA or immunoblot
assay."
12 - "The risk of acquiring either Lyme disease or babesiosis from a
blood transfusion in Connecticut is very low."
13 - Title: Lyme disease. [No abstract available.]
15 - "The existence of a form of early Lyme disease characterized by a
flu-like illness without erythema migrans is controversial. ...The
existence of a flu-like illness without erythema migrans of early
Lyme disease has been clearly established." COMMENT: The existence of
persisting or relapsing Lyme disease seems to be controversial for some
researchers. ........
16 - "Even in an area in which Lyme disease is endemic, the risk of
infection with B. burgdorferi after a recognized deer-tick bite is so
low that prophylactic antimicrobial treatment is not routinely
indicated." COMMENT: Lots of controversey on this paper evidenced by
the number of comments to it. See all comments at:
Antimicrobial Prophylaxis after Tick Bites, NEJM 1993; 328: 1418-1420
For more on prophylactic antibiotic treatment of tick bites, see:
Antibiotic Prophylaxis After Tick Bite For Prevention Of Lyme Disease -
An Annotated Bibliography
17 - Title: Diagnosis of Lyme disease in children. [No abstract
available.]
For more information on Lyme disease see:
Lots Of Links On Lyme Disease
Comments or questions concerning this page should be directed to
Art Doherty.
Last updated on 6 February 2000 by
Art Doherty
Lompoc, California
doherty@utech.net
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