RESEARCH
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| AUTHORS | Kozma L. Lenkey A. Varga E.Gomba S. |
| INSTITUTION | Department of Pathology, University Medical School of Debrecen, Hungary. |
| TITLE | Induction of renin release from isolated glomeruli by inorganic mercury(II) |
| SOURCE | Toxicology Letters. 85(1):49-54, 1996 Apr. |
| COUNTRY OF PUBLICATION | Netherlands |
| ABSTRACT | Mercury (II) ions are known to accumulate in the kidney and their effect upon the renin-angiotensin system has also been described. The question, however, whether mercury (II) also exerts direct effect on the juxtaglomercular cells (JGC) to induce renin release remain to be answered. Suspension of isolated glomeruli was used to measure the mercury(II) ion concentration as low as 1 micronM. The renin-releasing effect of the mercury(II) ion concentration as low as 1 microM. The renin-releasing effect of the mercury ion is to be inhibited by dithiothreitol (DDT) (renin activity 20.37 vs 2.60 ng/ml.h in supernatant) as well as the eleveated osmotic concentration of the incubating bath medium (20.37 vs. 6.84 ng/ml.h). This suggests that certain membrane sulfhydryl groups are implicated in teh processs on the one hand, and it is also in accordance with the known sensitivity of the renin granules to osmotic pressure on the other hand. Light and electron micrographs also demonstrate the direct, effective role of Hg(II) in the renin release process. Therefore, it is assumed that apart from its influence on tubulo-glomerular feedback a direct way of action of mercury (II) on renin release must also be taken into account. |
| PUBLICATION TYPE | Journal Article |
| LANGUAGE | English |
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