RESEARCH
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| AUTHORS | Danersund A; Lindvall A; Lindh U. |
| INSTITUTION | Dept of Clinical Immunology and Transfusion Medicine, Dept of Infectious Diseases and Centre for Metal Biology in Uppsala, Uppsala University. |
| TITLE | Metal Profiles in 25 Patients with Long-Term Illness |
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| ABSTRACT | INTRODUCTION: The aim of the study was to evaluate if removal of dental amalgam and medical support improves the health status of patients with long-term illness. Twenty-five patients were included in the study and they had all soft diagnoses from their physicians.
METHODS-Nuclear microscopy (1) was undertaken for isolated blood cells from venous sampling after three weeks without supplementation of trace elements and vitamins. RESULTS AND DISCUSSION: Anamnestically 16/25 display a story of contact-allergy against metals and/or cosmetic intolerance. The criteria of chronic fatigue syndrome were fulfilled by 12/25. Conspicuous deviations from normal elemental ranges were noted for magnesium, calcium and zinc. Elevated concentrations of calcium were consistent in both cell types as well as decreased zinc concentrations. Erythrocyte magnesium was often low in contrast to granulocyte magnesium which was often high. In addition, granulocyte manganese was always high. In both cell types there were conspicuous concentrations of strontium, an element never found in controls. We have further looked at cellular mercury. Levels exceeding the detection limit (0.5 ug/g dry weight) were found in 14/25 patients in 5-15% of the erythrocytes investigated. For the studied granulocytes, 20/25 patients displayed detectable mercury levels in 10-30% of the cells. CONLUSION: All patients have an elemental profile suggesting that heavy metal burden may influence their health. The elemental profiles in the patient group show similarities with those in inflammatory connective-tissue diseases (2).
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