CURICULUM VITAE
Alexander V.Spirov, PhD
I.M.Sechenov Institute of Evolutionary Physiology and
Biochemistry,
Russian Academy of Sciences,
44 Torez Pr., 194223 St-Petersburg, Russia
7 812 552 32 19 (phone) 7 812 552 30 12 (fax)
e- mail: spirov@iephb.ru
PERSONAL
date of birth 8 January 1955;
married, one child
EDUCATION
Leningrad State University, Faculty of Biology, Department of Biological
Chemistry and
Institute of Experimental Medicine, Department of Biochemical Genetics,
Leningrad
1972 - 1978
Graduate honors degree (=MS): Biochemistry - 1978. Leningrad
State University, Faculty of Biology, Department of Biological Chemistry,
St.Petersburg, Russia
Diploma: "Analysis of molecular structure of mitochondrial
DNA from rat liver by methods of electron microscopy", Department
of Biochemical Genetics, Institute of Experimental Medicine, (Advisor Prof.
Salamon A.Neifakh)
PostGraduate studentship:
Irkutsk State University, (Irkutsk), Dept. Physico-Chemical Biology
1979 - 1983
(Dynamical modeling, Computational Biology, Biometrics)
Candidate of Science (=PhD) - 1987. Irkutsk State University, Dept.
Physsico-Chemical Biology, Irkutsk, Russia
Thesis: "Investigation of seasonal dynamics of spatially
distributed communities of zooplankton by methods of theory of catastrophes",
(Advisor Prof.Juri P.Kozlov)
EXPERTISE SUMMARY
EXPERIENCE IN COMPUTATIONAL BIOLOGY & BIOINFORMATICS:
- Retrieving genome information via the E-mail, World Wide Web, FTP,
CD-ROM.
- Analysis of DNA and protein sequences via Analytical Servers.
- Development of software for DNA sequences analysis (Genetic Algorithms-based
strategies for search of gene regulatory regions).
- Development of hypermedia molecular-biological information systems:
hypertext DB, Java applets, scientific animation, image processing.
- Participation in development of Molecular Genetics Hypertext Encyclopaedia.
HARDWARE & OPERATING SYSTEMS
* Pentium running MS-DOS or Windows.
* DEC workstations running LINUX.
LANGUAGES
Extensive: Pascal (Borland Pascal, Borland Delphi).
Moderate: Fortran, C.
PROFESSIONAL EMPLOYMENT
Institute of High-Performance Computing and DataBases,
Ministry of Science
1986- present
Laboratory of Bioinformatic Systems
Position: Leading Scientific Researcher, the Head of the group
Major Accomplishments:
Curator of the "GENET" molecular-biological hypermedia information
system
Executor of the program of Ministry of Science and Technologies "SegNet,
the database on mechanisms of regulation of genes controlling embryogenesis
in Drosophila"
I.M.Sechenov Institute of Evolutionary Physiology and
Biochemistry,
Russian Academy of Sciences
1989-Present
Laboratory of Mathematical Modelling of Evolution and Computer Center
of the Institute
Position: Senior Scientific Researcher, the Head of the Group.
Major Accomplishments:
- Leading executor of the "HUMAN GENOME" (Russian Academy of
Sciences) projects entitled:
- "Data Bank of Conserved Regions of Mitochondrial Proteins and
Investigation of Evolution of Mitochondrial Proteins" (1992 - 1993)
- "Data bank of regulatory regions of human/mammalia homeo box-containing
genes and computer analysis of the regulatory regions" (1994)
- Executor of the "Russian Foundation for Basic Research" project
entitled: "Simulations of the processes in evolutionary and ecological
physiology" (1994-1997)
- The Head of the "Russian Foundation for Basic Research" project
entitled: "Phylogenetic analysis of the functional organization of
homeobox-genes networks as one of elements of the body plan of Animalia
kingdom" (1996-1997)
- The Head of the "Russian Foundation for Basic Research" project
entitled: "Evolutionary conservatism of cascades of genes-controllers
in regulation of ontogenesis: computer analysis of images of expression
patterns and simulation of dynamics of genetic networks/cascades"
(1998-1999)
- The Head of the "Russian Foundation for Basic Research" project
entitled: "HAZARD" hypermedia information system" (1998-1999)
- Supervisor of the "HOX-Pro" hypermedia information system
- Supervisor of the "HAZARD" hypermedia information system
Other activities:
- In frame of Russian HUMAN GENOM Project I participate in development
of Encyclopaedia Hypertext (Chapter about human/mammalian homeobox genes)
via FLEXIS Hypertext Encyclopaedia software (E.Golovanov, 1992).
- In outlook of coloborative biodiversity project I become acquainted
with ETI Biodiversity Information System Linnaeus II.
Second Leningrad Medical Institute, Academy of Medical
Sciences 1983-1989
Department of Biology and Genetics, assistant
Major Accomplishments:
Practical courses in "General Biology and Genetics"
Computer Center of the Institute, researcher
Major Accomplishments:
Medial/biological data treatment.
Irkutsk State University, Irkutsk (East Siberia)
1979-1983
Department of Physico-Chemical Biology, postgraduate student.
Computer Center of the University, technician-programmer.
Major Accomplishments:
Hydrobiological data treatment; Development of Baikal lake' plankton
databank.
EMPLOYMENT DURING SCHOOL
Institute of Experimental Medicine (Leningrad) 1974-1978
As technical assistant and pre-graduate student I had a share in working
with mitochondrial F9 ATP-ase subunit gene (localised in mt genome of S.cerevisiae)
and in restriction analysis of rat mt DNA.
FOREIGN LANGUAGES
TOEFL Score - 523, SFO St.Petersburg, 01.23.93.
Can read German.
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