Bloaty.
Beverly Bighead - Toad. Rocko's neighbor, Ed's wife, Ralph's mother. Voice: Charlie Adler.
Bloaty.
Chuck Chameleon - Leon's brother. (I'm not sure which is which).
Cindy Wolfe - Heffer's adopted sister.
Earl - Mrs. Bighead's dog.
Ed Bighead - Toad. Rocko's neighbor, Beverly's husband, Ralph's father. Voice: Charlie Adler.
Filburt Shellbache - Turtle. Married to Paula Hutchison. Voice: Lawrence.
Flecko.
Gladys the Hippo Lady. Voice: Charlie Adler.
George Wolfe - Heffer's adopted father. Voice: Charlie Adler.
Heffer Wolfe - Voice: Tom Kenny.
Hiram "Willie" Wolfe - Heffer's adopted grandfather. Voice: Charlie Adler.
Leon Chameleon - Chuck's brother. (I'm not sure which is which).
Mr. Smitty.
Paula Hutchison, Dr. - Cat. Married to Filburt Shellbache. Voice: Linda Wallem.
Peter Wolfe - Heffer's adopted brother.
Ralph Bighead - Toad. Son of Beverly and Ed. Voice: Joe Murray.
Rocko - Wallaby. Voice: Carlos Alazraqui.
Spunky - Rocko's dog. Vocie: Carlos Alazraqui
Squirmy.
Virginia Wolfe - Heffer's adopted mother. Voice: Linda Wallem.