Periportal ± Bridging Necrosis | Score | Intralobular Degeneration and Focal Necrosis | Score | Portal Inflammation | Score | Fibrosis | Score |
None | 0 | None | 0 | No portal inflammation | 0 | No Fibrosis | 0 |
Mild piecemeal necrosis | 1 | Mild (acidophilic bodies, ballooning degeneration and/or scattered foci of hepatocellular necrosis in 1/3 of lobules or nodules) | 1 | Mild (sprinkling of inflammatory cells in <1/3 of portal tracts) | 1 | Fibrous portal expansion | 1 |
Moderate piecemeal necrosis (involves <50% of the circumference of most portal tracts) | 3 | Moderate
(involvement of
1/3-2/3 of lobules or nodules) |
3 | Moderate (increased inflammatory cells in 1/3-2/3 of portal tracts) | 3 | Bridging Fibrosis (portal-portal or portal-central linkage) | 3 |
Marked
piecemeal
necrosis (involves >50% of the circumference of most portal tracts) |
4 | Marked (involvement of >2/3 of lobules or nodules) | 4 | Marked (dense packing of inflammatory cells in >2/3 of portal tracts) | 4 | Cirrhosis | 4 |
Moderate piecemeal necrosis plus bridging necrosis | 5 | ||||||
Marked piecemeal necrosis plus bridging necrosis | 6 | ||||||
Multilobular necrosis | 10 |