Histology Activity Index
(HAI-Knodell Scoring)


 



 
Periportal ± Bridging Necrosis Score Intralobular Degeneration and Focal Necrosis Score Portal Inflammation Score Fibrosis Score
None     0  None     0 No portal inflammation     0 No Fibrosis     0
Mild piecemeal necrosis     1 Mild (acidophilic bodies, ballooning degeneration and/or scattered foci of hepatocellular necrosis in 1/3 of lobules or nodules)     1 Mild (sprinkling of inflammatory cells in  <1/3 of portal tracts)     1 Fibrous portal  expansion     1
Moderate piecemeal necrosis (involves <50% of the circumference of most portal tracts)     3 Moderate (involvement of
1/3-2/3 of lobules or nodules)
    3 Moderate (increased           inflammatory cells in 1/3-2/3 of portal tracts)     3 Bridging Fibrosis (portal-portal or portal-central  linkage)     3
Marked piecemeal
necrosis (involves >50% of
the circumference of most portal tracts)
    4 Marked (involvement of >2/3 of lobules or nodules)     4 Marked (dense packing of inflammatory cells in >2/3 of portal tracts)     4  Cirrhosis     4
Moderate piecemeal necrosis plus bridging necrosis     5
Marked piecemeal necrosis plus bridging necrosis     6
Multilobular necrosis     10



TOTAL HAI (Knodell Score) = __/22





Reference:  Knodell RG, et al. Formulation and Application of a Numerical Scoring System For Assessing Histological Activity in Asymptomatic Chronic Active Hepatitis,Hepatology 1981; 1(5):431-5



 
 
 
 
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