Definitions:
- Anti-HCV: Antibody to hepatitis C Virus.
- ALT: Liver enzyme released from liver cells that are injured, eg: by virus, alcohol, fat, drug, etc.
- RIBA-2: Supplimental test to detect antibody to hepatitis C Virus.
- Indeterminate: 1 of 4 antigens positive.
HCV-RNA PCR: (Polymerase Chain Reaction) determines whether the virus is multiplying.
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Recommendation |
| Anti-HCV (EIA-2) | Positive | Chronic hepatitis, chronic hepatitis C recovered, recent acute hepatitis C, or false positive test | Further evaluation |
| Anti-HCV (EIA-2)
ALT Supplemental test (RIBA-2) |
Positive
Normal Positive |
Possible chronic HCV carrier, may have chronic hepatitis C | Further evaluation by HCV RNA PCR test |
| Anti-HCV (EIA-2)
ALT |
Positive
Elevated |
Presume chronic hepatitis C | Further evaluation by HCV RNA PCR test/consider Interferon Therapy |
| Anti-HCV (EIA-2)
ALT Supplemental test (RIBA-2) |
Positive
Normal Negative or indeterminate |
Presume false positive anti-HCV or recovered | Further evaluation by HCV RNA PCR test if RIBA2 negative or indeterminate |
| Anti-HCV (EIA-2)
ALT HCV RNA PCR |
Positive
Elevated Negative |
Presume false positive anit-HCV | Further evaluation for liver disease other than hepatitis C |
| ALT
(no other symptoms) |
Elevated | possible fatty liver, chornic viral hepatitis, alcoholic liver disease, hemochromatosis, drug induced liver injury, other liver disease | Further Evaluation |
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