Sentience
This is the $64,000 question: Who's got the brains on your world? What specie(s) in the course of your world's development figured out how to not only crawl out from under a rock but to pick up said rock and hurl it to bring down dinner? It's the intelligent creatures that will make fire, build houses, forge weapons, found empires, sing lusty songs, and otherwise leave a lasting mark on your world. The Sentience section will give you some tips in selecting these distinguished creatures who will be the major players in the drama of your world.