My name is Jane Vasco. I work for a secret government agency that hunts Neuros, people who can do dangerous things with their minds. On my first assignment, something a little weird happened. Ok, something REALLY weird. Til I get some answers I'm getting on with my life, doing my job, stocking up on aspirin. Because, I gotta tell you -- pain's a bitch!
Season One  | 22 color episodes in 60 minute format | |||
|---|---|---|---|---|
| Ep | PN | Airdate | Title | |
| Dec 10/05 | Painkiller Jane (120 mins) | |||
| 1 | 101 | Apr 13/07 | Pilot | |
| 2 | 102 | Apr 20/07 | Toy Soldiers | |
| 3 | 105 | Apr 27/07 | Piece of Mind | |
| 4 | 108 | May 04/07 | Catch Me if You Can | |
| 5 | 106 | May 11/07 | Nothing to Fear But Fear Itself | |
| 6 | 104 | May 18/07 | Breakdown | |
| 7 | 103 | Jun 01/07 | Higher Court | |
| 8 | 111 | Jun 08/07 | Friendly Fire | |
| 9 | 110 | Jun 15/07 | Trial By Fire | |
| 10 | 109 | Jun 22/07 | Lauren Gray | |
| 11 | 107 | Jun 29/07 | Ghost in the Machine | |
| 12 | 113 | Jul 06/07 | Something Nasty in the Neighborhood | |
| 13 | 112 | Jul 13/07 | The League | |
| 14 | 115 | Jul 20/07 | The Amazing Howie | |
| 15 | 114 | Jul 27/07 | The Healer | |
| 16 | 116 | Aug 03/07 | Thanks For the Memories (clip show) | |
| 17 | 117 | Aug 17/07 | Playback | |
| 18 | Aug 24/07 | Jane 113 | ||
| 19 | Aug 31/07 | What Lies Beneath | ||
| 20 | Sep 07/07 | The Beast of Bolnar | ||
| 21 | Sep 14/07 | Reflections | ||
| 22 | Sep 21/07 | Endgame | ||
