DNA
(abbreviation for deoxyribonucleic acid)
Complex giant molecule that contains, in chemically coded form, the information needed for
a cell to make proteins. DNA is a ladderlike double-stranded nucleic
acid which forms the basis of genetic
inheritance in all organisms, except for a few viruses that have only RNA.
DNA is organized into chromosomes and, in organisms other
than bacteria, it is found only in the cell nucleus.
Structure
DNA is made up of two chains of nucleotide subunits, with each nucleotide containing either a purine (adenine or guanine) or
pyrimidine (cytosine or thymine) base. The bases link up with each other
(adenine linking with thymine, and cytosine with guanine) to form base
pairs that connect the two strands of the DNA molecule like the rungs of a twisted
ladder. heredity The specific way in which the pairs form means that the base sequence is
preserved from generation to generation.
Hereditary
Information is stored as a specific sequence of bases. A set of three
bases - known as a codon - acts
as a blueprint for the manufacture of a particular amino acid,
the subunit of a protein molecule
codons
Geneticists identify the codons by the initial letters of the constituent bases - for
example, the base sequence of codon CAG is cytosine-adenine-guanine. The meaning of each
of the codons in the
genetic code has been worked out by molecular geneticists. There are four different bases,
which means that there must be 4 ´ 4 ´ 4 = 64 different codons. Proteins are usually
made up of only 20
different amino acids, so many amino acids have more than one codon (for example, GGT,
GGC, GGA and GGG all code for the same amino acid, glycine.)
blueprint for the organism.
The information encoded by the codons is transcribed (see transcription) by messenger RNA
and is then translated into amino acids in the ribosomes and cytoplasm. The sequence of
codons determines the precise order in which amino acids are linked up during manufacture
and, therefore, the kind of
protein that is to be produced. Because proteins are the chief structural molecules of
living matter and, as enzymes, regulate all aspects of metabolism, it may be seen that the
genetic code is effectively
responsible for building and controlling the whole organism.
laboratory techniques
The sequence of bases along the length of DNA can be determined by
cutting the molecule into small portions, using
restriction enzymes. This technique can also be used for transferring specific sequences
of DNA from one organism to another
Ancient DNA
The oldest sequenced DNA to be found is that of a nemonychid weevil trapped in amber from
the Cretaceous period, and estimated as being 120-135 million years old. US researchers
extracted DNA from human hair 10,000 years old 1994. Dinosaur DNA was extracted 1994 from
unfossilized dinosaur bones found in a coal mine in Utah.
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