Genetics
The science of heredity that attempts to explain how characteristics
are passed on from one generation to the next. The founder of genetics was Austrian
biologist Gregor Mendel, whose experiments with
peas showed that inheritance of characteristics takes place by means of discrete
`particles´, later called
genes.
Before Mendel, it had been assumed that the characteristics of the two parents were
blended during inheritance, but Mendel showed that the genes remain intact, although their
combinations change.
Since Mendel, genetics has advanced greatly, first through breeding experiments and
light-microscope
observations (classical genetics), later by means of biochemical and electron-microscope
studies
(molecular genetics).
In 1944, Oswald Avery, Colin McLeod, and Maclyn McCarty showed that
the genetic material was
deoxyribonucleic acid (DNA), and not protein as was previously
thought. A further breakthrough was made when, in 1953, James Watson and Francis Crick
published their molecular model for the structure of DNA, the double helix, based on X-ray
diffraction photographs. The following decade saw cracking of the genetic code. The
genetic code is said to be universal since the same code applies to all organisms from
bacteria and viruses to higher plants and animals, including humans. Today the deliberate
manipulation of genes by biochemical techniques, or genetic engineering, is
commonplace. See also genotype, phenotype, and monohybrid inheritance.
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