Poser Criteria
Diagnosing Multiple Sclerosis

An exacerbation is defined as:
• the appearance of a new clinical Sign/Symptom
• or the clinical worsening of a previous Sign/Symptoms
  that had been stable for at least the previous 30 days
• and which persisted for a minimum of 24 hours.

Source:
Poser, CM; Paty, DW; Scheinber, L; et al.
Ann Neurol 1983; 13(3); 227-231
"New Diagnostic Criteria For Multiple Sclerosis; Guidelines For Research Protocols"

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Diagnostic Categories for Multiple Sclerosis
Definite MS:		Consistent course (Relapsing/Remitting) with at least 2 bouts, separated by at least 1 month; or slow, stepwise Progressive course for at least 6 months
		Documented Neurologic Signs of Lesions in more than one area (Functional System) of Brain or Spinal Cord White Matter
		Onset of Symptoms between 10 and 50 years of age
		Absence of other more likely Neurologic explanation
Probable MS:		History of Relapsing/Remitting Symptoms
		Signs not documented and only one current Sign, commonly associated with MS
		Documented single bout of Symptoms with Signs, of more than one White Matter Lesion
		Good recovery, then variable Symptoms and Signs
		Absence of other more likely Neurologic explanation
Possible MS:		History of Relapsing/Remitting Symptoms
		No documentation of Signs establishing more than one White Matter Lesion
		Absence of other more likely Neurologic explanation

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Source
MRI & Poser Criteria
David H. Miller MB, ChB, MD, FRACP
Institute of Neurology, MS NMR Research Unit, London, UK

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