In addition, many physicians are unaware that normal or near-normal lab results CANNOT eliminate a lupus diagnosis in a patient with reports of extensive systemic complaints. Even fewer physicians realize that fluctuating laboratory results in a lupus patient are not necessarily in direct proportion to disease activity. It is possible for a patient with the Anticoagulant Syndrome to suffer a stroke, (or TIA) while Sedimentation Rate, blood compliments, spinal fluid, and anti-DNA may all be normal. Individuals with SLE will, from time to time throughout the course of their disease, have ANA (Anti-Nuclear Antibodies) results ranging from very low titers to high titers, and can even have negative results in the height of illness. However, perfectly healthy individuals, as well as those with some other autoimmune diseases, can have a positive ANA, so this alone cannot establish a lupus diagnosis. Because of inadequate education in SLE, many physicians will not even think to test a patient for lupus -- especially a man or child -- while others are too quick to give a lupus diagnosis without adequate findings. It is believed by some Rheumatologists that many patients who have been diagnosed with Systemic Lupus actually have Fibromyalgia (FM) instead. While FM can be quite functionally-disabling, and it shares many symptoms with SLE, FM does not cause organ damage and it is not life-threatening.

While low platelet and white cell counts are listed among the diagnostic criteria, many physicians are unaware that elevated platelet and white cell counts can be indicative of "Vasculitis" ~~ a secondary condition which is quite common in SLE. In fact, a great majority of lupus symptoms can be traced to this vascular conditon, especially in those patients with the Anticoagulant Syndrome.

Another mis-conception is that lupus patients who suffer Central Nervous System (CNS) involvement will always show the presense of anti-native DNA antibodies. While this antibody certainly leads to a definite Lupus-CNS diagnosis, there remain a great many lupus patients without this antibody who present CNS involvement. It has recently been discovered that cognitive dysfunctions can also be traced to low-levels of oxygen in the blood, especially in those in who experience such vascular disorders as migraine headaches, Raynaud's Phenomenon, and the Anticoagulant Syndrome. This is thought to be a result of restricted blood flow to the brain due to inflammation of blood vessels in most patients, but could also be a result of abnormalities in the Autonomic Nervous System. While 50% of lupus patients have the anti-DNA antibody, (meaning 50% do not) as many as 75% report cognitive impairments.